RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
直肠腺癌患者肿瘤微环境中免疫细胞亚群的预后价值
英文原题：Prognostic Value of Immune Cells Subsets Within the Tumor Microenvironment in Patients With Rectal Adenocarcinoma.
查看英文原题
Prognostic Value of Immune Cells Subsets Within the Tumor Microenvironment in Patients With Rectal Adenocarcinoma.
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研究概要
肿瘤微环境中的免疫细胞亚群，包括 CD3、CD8 和 CD45RO，是 READ 患者的独立预后因素。
研究思路结论见上方概要
背景
三分之一新诊断的结直肠癌病例为直肠癌。包括手术、放疗和化疗在内的多模式治疗方案改善了直肠腺癌（READ）患者的局部控制和生存结局，并减少了肿瘤复发。然而，迫切需要通过对患者进行分层来预测其治疗反应，以提高治疗效果。
方法
采用免疫组织化学方法评估了279例READ患者肿瘤微环境中CD3+、CD8+和CD45RO+免疫细胞亚群的免疫染色情况。
结果
在本研究中，我们发现通过量化CD3+、CD8+和CD45RO+免疫细胞亚群来检测适应性免疫反应，可为READ患者提供改进且独立的预后价值。无论常规临床和病理参数如何，T细胞亚群的密度与READ患者更好的预后密切相关。肿瘤内免疫细胞高密度与无淋巴结转移、无淋巴血管侵犯和无神经周围侵犯相关。此外，高TIL（肿瘤浸润淋巴细胞）亚群与READ患者良好的生存结局相关，尤其是晚期READ高危患者。
展开英文摘要原文
PATIENTS AND METHODS
Immunostainings of CD3 + , CD8 + , and CD45RO + immune cell subsets within the tumor microenvironment were evaluated using immunohistochemistry in two hundred seventy-nine READ patients.
RESULTS
In this study, we found that examination of the adaptive immune response by quantifying CD3 + , CD8 + , and CD45RO + immune cell subsets, provides improved and independent prognostic value for patients with READ. Regardless of conventional clinical and pathologic parameters, the densities of T cell subsets were strongly related to a better prognosis in patients with READ. High density of intratumoral immune cells is associated with absence of nodal metastasis, lymphovascular invasion, and perineural invasion. Moreover, high tumor-infiltrating lymphocyte (TIL) subsets were associated with favorable survival outcome in patients with READ, especially high-risk patients with advanced READ.
CONCLUSION
Immune cell subsets including CD3, CD8, and CD45RO within the tumor microenvironment were independent prognostic factors for patients with READ.
论文信息
- 作者
- Ke TW、Zwane ST、Chiang SF、Chen TW、Yang PC、Chen LC、Lin YS、Chen WT
- 第一作者单位
- Department of Colorectal Surgery, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.China
- 通讯作者单位
- Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, R.O.C.; chihyang0425@mail.cmu.edu.tw.China
- 期刊
- Anticancer research2024 Feb
- 原文标识
- PubMed 38307574 · DOI 10.21873/anticanres.16870