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目前关于利用树突状细胞在癌症免疫治疗中力量的知识现状与挑战

英文原题:Current state of knowledge and challenges for harnessing the power of dendritic cells in cancer immunotherapy.

查看英文原题

Current state of knowledge and challenges for harnessing the power of dendritic cells in cancer immunotherapy.

PubMed 2023/12/12(内容时间) Pathol Res Pract Q1 · IF 3.7(JCR 2025)

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中文摘要

DC在癌症免疫治疗中具有巨大前景,并且对于协调免疫反应至关重要。在抗击癌症的过程中,利用DC刺激免疫系统并将其聚焦于肿瘤细胞的能力已被证明是一种可行的策略。本研究全面概述了DC用于癌症免疫治疗的最新进展以及潜在的未来方向。本研究回顾了DC治疗中使用的多种方法,例如疫苗接种和过继性细胞免疫治疗。这些研究强调了基于DC的治疗对转移性去势抵抗性前列腺癌和非小细胞肺癌的有效性和安全性。研究结果表明,特定患者群体具有更长的生存时间和更优的结果。不过,我们也认识到基于DC的免疫治疗所面临的困难和局限。这些包括免疫抑制性肿瘤微环境、DC生产的复杂性以及DC群体内部的异质性。需要更多研究和发展来克服这些挑战,以增强免疫反应、优化治疗方案并提高可扩展性。

展开英文摘要原文

DCs have great promise for cancer immunotherapy and are essential for coordinating immune responses. In the battle against cancer, using DCs' ability to stimulate the immune system and focus it on tumor cells has shown to be a viable tactic.

This study offers a thorough summary of recent developments as well as potential future paths for DC-based immunotherapy against cancer.

This study reviews the many methods used in DC therapy, such as vaccination and active cellular immunotherapy. The effectiveness and safety of DC-based treatments for metastatic castration-resistant prostate cancer and non-small cell lung cancer are highlighted in these investigations. The findings indicate longer survival times and superior results for particular patient groups.

We are aware of the difficulties and restrictions of DC-based immunotherapy, though. These include the immunosuppressive tumor microenvironment, the intricacy of DC production, and the heterogeneity within DC populations. More study and development are needed to overcome these challenges to enhance immunological responses, optimize treatment regimens, and increase scalability.

论文信息

作者
Shbeer AM
单位
Department of Surgery, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia. Electronic address: ashbeer@jazanu.edu.sa.Saudi Arabia
文献类型
综述
期刊
Pathology, research and practice2024 Jan
原文标识
PubMed 38147726 · DOI 10.1016/j.prp.2023.155025