CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞对修饰后 MCF-7 乳腺癌细胞系的细胞毒性作用
英文原题：Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line.
查看英文原题
Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line.
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中文摘要
乳腺癌是女性最常见的诊断癌症，也是导致女性死亡最多的恶性肿瘤。国际癌症研究机构（IARC）估计，2020年新增病例达226万例。采用嵌合抗原受体改造T细胞的过继细胞治疗，在乳腺癌等实体瘤治疗中显示出潜力。本研究评估了CAR-T 细胞对由改造后的MCF-7乳腺癌细胞构成的单层模型和三维生物打印类肿瘤结构的杀伤效果。研究还测定了MCF-7肿瘤细胞模型与CAR-T 细胞共培养后上清液中的细胞因子谱，以揭示这种相互作用相关的炎症背景。
展开英文摘要原文
The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (IARC) estimates that there are 2. 26 million new cases of cancer in 2020. Adoptive cell therapy using T cells with chimeric antigen receptor shows potential for the treatment of solid tumors, such as breast cancer.
In this work the effectiveness of CAR-T cells against monolayer and three-dimensional bioprinted tumor-like structures made of modified MCF-7 breast cancer cells was assessed. The cytokine profile of supernatants after co-cultivation of MCF-7 tumor cell models with CAR-T cells was also measured to reveal the inflammatory background associated with this interaction.
论文信息
- 作者
- Valiullina AK、Zmievskaya EA、Ganeeva IA、Zhuravleva MN、Garanina EE、Rizvanov AA、Petukhov AV、Bulatov ER
- 单位
- Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.Russia
- 期刊
- Molecular biology research communications2023
- 原文标识
- PubMed 37886737 · DOI 10.22099/mbrc.2023.47125.1820
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