CD103(+) 组织驻留记忆 T 细胞在预测食管癌免疫检查点抑制剂疗效中的意义

Immune checkpoint inhibitors (ICIs), including nivolumab, have been approved to treat esophageal cancer. However, these remedies are not fit for all patients with esophageal cancer; therefore, a predictive surrogate marker is needed to assess their effectiveness. CD103 + CD8 + tumor-infiltrating lymphocytes, defined as tissue-resident memory T cells (T RM ), are promising indicators of response to ICIs, but it remains to be elucidated. This study investigated the association between the efficacy of ICIs and T RM .

The relationships between T RM infiltrating esophageal cancer, clinicopathological features, and prognosis after nivolumab initiation were examined using immunostaining. Tissue samples were obtained from surgically resected specimens of 37 patients with esophageal cancer who received nivolumab as a secondary or subsequent therapy. In addition, T RM infiltration was compared with programmed death-ligand 1 (PD-L1) expression and blood count parameters as predictors of nivolumab effectiveness.

T RM -rich patients had a significant survival benefit after nivolumab initiation (12-months overall survival 70.8% vs 37.2%, p = 0.0485; 12-months progression-free survival 31.2% vs 0%, p = 0.0153) and experienced immune-related adverse events more frequently than T RM -poor patients (6 vs 2 patients). T RM infiltration was weakly correlated with PD-L1 positivity (r = 0.374, p = 0.022), but T RM may indicate more sensitive response to ICIs than PD-L1 expression in this study. Some blood test parameters also weakly correlated with T RM but did not impact prognosis.

T RM -rich patients have a favorable prognosis after nivolumab initiation. Our results suggest that T RM are vital for antitumor immunity and are a promising predictor of ICIs effectiveness.