TP53 缺失通过上调 NF-κB-IFN-β-MHC-Ia 信号促进骨肉瘤对 NK 细胞的抵抗
TP53 Loss Elevates NF-κB-IFN-β-MHC-Ia Signaling to Promote NK Cell Resistance in Osteosarcoma.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
间充质干细胞疗法在肿瘤微环境中应用的新见解：利与弊
英文原题：New insights in application of mesenchymal stem cells therapy in tumor microenvironment: pros and cons.
查看英文原题
New insights in application of mesenchymal stem cells therapy in tumor microenvironment: pros and cons.
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中文摘要
多能间充质干细胞（MSC）被广泛认为可用于包括恶性肿瘤在内多种疾病的细胞治疗，其治疗作用主要归因于免疫调节和免疫抑制特性。尽管MSC在癌症治疗中显示出良好前景，越来越多证据也表明MSC在肿瘤微环境（TME）中可能具有促肿瘤特性，从而诱发肿瘤并促进其进展。鉴于MSC应用范围广，这一问题需要解决，以便其安全用于临床。本文回顾MSC在TME中的多种作用，并强调将其促肿瘤特征转变为抑癌效应的潜在方法。
展开英文摘要原文
Multipotent mesenchymal stem cells (MSCs) are widely accepted as a useful tool for cell-based therapy of various diseases including malignancies. The therapeutic effects of MSCs are mainly attributed to their immunomodulatory and immunosuppressive properties.
Despite the promising outcomes of MSCs in cancer therapy, a growing body of evidence implies that MSCs also show tumorigenic properties in the tumor microenvironment (TME), which might lead to tumor induction and progression. Owing to the broad-spectrum applications of MSCs, this challenge needs to be tackled so that they can be safely utilized in clinical practice.
Herein, we review the diverse activities of MSCs in TME and highlight the potential methods to convert their protumorigenic characteristics into onco-suppressive effects.
论文信息
- 作者
- Afkhami H、Mahmoudvand G、Fakouri A、Shadab A、Mahjoor M、Komeili Movahhed T
- 第一作者单位
- Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.Iran
- 通讯作者单位
- Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran.Iran
- 文献类型
- 综述
- 期刊
- Frontiers in cell and developmental biology2023
- 原文标识
- PubMed 37849741 · DOI 10.3389/fcell.2023.1255697
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →