基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
局部晚期乳腺癌患者新辅助化疗后 TIL（肿瘤浸润淋巴细胞）水平变化与残留肿瘤的关系
英文原题：Relationship between the change in tumour-infiltrating lymphocyte level and residual tumour after neoadjuvant chemotherapy in patients with locally advanced breast cancer.
查看英文原题
Relationship between the change in tumour-infiltrating lymphocyte level and residual tumour after neoadjuvant chemotherapy in patients with locally advanced breast cancer.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
本研究评估了 84 例局部晚期乳腺癌（LABC）患者新辅助化疗（NAC）前后乳腺组织中的TIL（肿瘤浸润淋巴细胞）比例及其对生存的影响。分别使用活检标本和手术标本测定 NAC 前后的 TIL 水平。NAC 前后 TIL 中位比例分别为 17.5% 和 5%，差异显著。NAC 前后 Ki-67 指数、分子亚型、NAC 前后 TIL 浓度以及术前残余癌负荷中的 TIL，均与病理完全缓解（pCR）显著相关。
具体而言，NAC 前 TIL 水平较高与 pCR 率较高相关。术后 Ki-67 指数和 pCR 可显著预测无病生存期（DFS）；术后 Ki-67 指数也可显著预测总生存期。DFS 的独立预后因素为术后 Ki-67 评分（风险比 [HR]：6.16；p = 0.012）、NAC 后 TIL 评分（HR：0.42；P = 0.041）和 pCR（HR：0.10；P = 0.038）。
本研究证实，较高的 NAC 前 TIL 水平和较低的术后 TIL 水平可能是 DFS 较长的替代指标；术后 TIL 比例还可能预测 LABC 患者 NAC 后是否达到 pCR。
展开英文摘要原文
To evaluate the tumour-infiltrating lymphocyte (TIL) rates in breast tissue before and after neoadjuvant chemotherapy (NAC) and their impact on survival, eighty-four patients with locally advanced breast cancer (LABC) were assessed. Pre- and post-NAC TIL levels were determined using biopsy and surgical specimens, respectively. The median TIL rate was significantly different before (17. 5%) and after (5%) NAC. Pre- and postoperative Ki-67 index, molecular subtype, pre- and post-NAC TIL concentration, and preoperative residual-cancer-burden TIL were significantly associated with pathological complete response (pCR).
Specifically, higher pre-NAC TIL levels were associated with higher pCR rates. Postoperative Ki-67 index and pCR, and postoperative Ki-67 index were significant predictors of disease-free (DFS) and overall survival, respectively. The independent prognostic factors for DFS were postoperative Ki-67 score (hazard ratio [HR]: 6. 16; p = 0. 012), post-NAC TIL score (HR: 0. 42; P = 0. 041), and pCR (HR: 0. 10; P = 0. 038).
Our study confirms that higher pre-NAC and lower postoperative TIL levels may be surrogate factors for longer DFS, and postoperative TIL rate may predict post-NAC pCR in patients with LABC.
论文信息
- 作者
- Erol VB、Goktas Aydin S、Bilici A、Cakir A、Acikgoz O、Olmez OF、Basim P
- 第一作者单位
- Department of Medical Oncology, Medical Faculty, Istanbul Medipol University, Istanbul, Turkey.Turkey
- 通讯作者单位
- Department of Surgery, Medical Faculty, Istanbul Medipol University, Istanbul, Turkey.Turkey
- 期刊
- Journal of chemotherapy (Florence, Italy)2023 Nov
- 原文标识
- PubMed 37599454 · DOI 10.1080/1120009X.2023.2247207