RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
结直肠癌的免疫治疗与免疫逃逸
英文原题：Immunotherapy and immunoevasion of colorectal cancer.
查看英文原题
Immunotherapy and immunoevasion of colorectal cancer.
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中文摘要
免疫治疗在临床试验中取得的巨大成功，已使其成为癌症治疗的新支柱。然而，在构成大多数CRC肿瘤的微卫星稳定结直肠癌（MSS-CRC）中，临床疗效甚微。在此，我们讨论CRC的分子和遗传异质性。我们回顾免疫逃逸机制，并重点关注免疫治疗作为CRC治疗手段的最新进展。通过更好地理解肿瘤微环境（TME）和免疫逃逸的分子机制，本综述为开发对不同CRC亚群患者有效的治疗策略提供了见解。
展开英文摘要原文
The tremendous success of immunotherapy in clinical trials has led to its establishment as a new pillar of cancer therapy.
However, little clinical efficacy has been achieved in microsatellite stable colorectal cancer (MSS-CRC), which constitutes most CRC tumors.
Here, we discuss the molecular and genetic heterogeneity of CRC.
We review the immune escape mechanisms, and focus on the latest advances in immunotherapy as a treatment modality for CRC. By providing a better understanding of the tumor microenvironment (TME) and the molecular mechanisms underlying immunoevasion, this review offers an insight into developing therapeutic strategies that are effective for patients with various subsets of CRC.
论文信息
- 作者
- Al Zein M、Boukhdoud M、Shammaa H、Mouslem H、El Ayoubi LM、Iratni R、Issa K、Khachab M
- 第一作者单位
- Faculty of Medical Sciences, Lebanese University, Hadath, Beirut, Lebanon.Lebanon
- 通讯作者单位
- Department of Basic Medical Sciences, College of Medicine, Qatar University, QU Health, Doha, Qatar. Electronic address: ali.eid@qu.edu.qa.Qatar
- 文献类型
- 综述
- 期刊
- Drug discovery today2023 Sep
- 原文标识
- PubMed 37328052 · DOI 10.1016/j.drudis.2023.103669