基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CDK4/6 抑制剂的免疫调节作用
英文原题：Immunomodulatory effects of CDK4/6 inhibitors.
查看英文原题
Immunomodulatory effects of CDK4/6 inhibitors.
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中文摘要
细胞周期失调是癌症的标志之一。细胞周期蛋白依赖性激酶4（CDK4）和CDK6在调控细胞周期及其他细胞功能中发挥关键作用。CDK4/6抑制剂在治疗乳腺癌方面取得了巨大成功，目前也正在其他肿瘤类型中广泛开展试验。越来越多的证据表明，CDK4/6抑制剂除诱导细胞周期阻滞外，还通过免疫调节发挥抗肿瘤作用。本文概述了CDK4/6抑制剂的免疫调节活性，讨论了耐药的免疫机制，并探索了将其与免疫检查点抑制剂（ICIs）或嵌合抗原受体（CAR）T细胞疗法联合以改善临床结局、发挥其免疫治疗潜力的途径。
展开英文摘要原文
The dysregulation of the cell cycle is one of the hallmarks of cancer. Cyclin-dependent kinase 4 (CDK4) and CDK6 play crucial roles in regulating cell cycle and other cellular functions. CDK4/6 inhibitors have achieved great success in treating breast cancers and are currently being tested extensively in other tumor types as well. Accumulating evidence suggests that CDK4/6 inhibitors exert antitumor effects through immunomodulation aside from cell cycle arrest.
Here we outline the immunomodulatory activities of CDK4/6 inhibitors, discuss the immune mechanisms of drug resistance and explore avenues to harness their immunotherapeutic potential when combined with immune checkpoint inhibitors (ICIs) or chimeric antigen receptor (CAR) T-cell therapy to improve the clinical outcomes.
论文信息
- 作者
- Zhang S、Xu Q、Sun W、Zhou J、Zhou J
- 第一作者单位
- Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.China
- 通讯作者单位
- Department of Respiratory Disease, Thoracic Disease Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: zhoujy@zju.edu.cn.China
- 文献类型
- 综述 · 非美国政府资助研究
- 期刊
- Biochimica et biophysica acta. Reviews on cancer2023 Jul
- 原文标识
- PubMed 37182667 · DOI 10.1016/j.bbcan.2023.188912