基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
乳腺癌中程序性死亡配体-1 (PD-L1) 和 TIL（肿瘤浸润淋巴细胞）(TILs) 的表达及其临床意义
英文原题：Expression of programmed death ligand-1 (PD-L1) and tumor infiltrating lymphocytes (TILs) in breast carcinoma and their clinical significance.
查看英文原题
Expression of programmed death ligand-1 (PD-L1) and tumor infiltrating lymphocytes (TILs) in breast carcinoma and their clinical significance.
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研究概要
PD-L1 和 TILs 均在 3 级乳腺癌中显示最高阳性率。
研究思路结论见上方概要
背景
乳腺癌是女性癌症死亡的第二大原因。癌细胞中程序性死亡配体-1（PD-L1）的表达在个体化治疗中起重要作用。这可以通过在福尔马林固定和石蜡包埋（FFPE）标本中使用单克隆PD-L1抗体进行免疫组织化学来评估。我们的目的是评估浸润性乳腺癌中PD-L1和TIL（肿瘤浸润淋巴细胞）（TILs）的表达及其与临床病理的相关性。
方法
对50例经组织学诊断的乳腺癌石蜡包埋组织进行了PD-L1和TIL的免疫组化染色。使用Statistical Package for the Social Sciences (SPSS) 22软件进行统计分析。
结果
在这50例中，PD-L1和TIL表达分别见于16例（32%）和18例（36%）。PD-L1阳性见于33.33%的1级乳腺癌病例、13.79%的2级乳腺癌病例以及75%的3级乳腺癌病例。TIL在6.9%的1级乳腺癌病例、13.79%的2级乳腺癌病例以及100%的3级乳腺癌病例中显示阳性。具有PD-L1表达的患者比例在3级癌中高于1级或2级。差异具有统计学意义（卡方值=13.417，自由度=1，P<0.05）。TIL的卡方值为28.07，自由度为1，P值<0.05，具有统计学意义。
展开英文摘要原文
MATERIALS AND METHODS
Immunohistochemical staining for PD-L1 and TILs was done in paraffin-embedded tissues of histologically diagnosed 50 cases of breast carcinoma. Statistical analysis was done using Statistical Package for the Social Sciences (SPSS) 22 software.
RESULTS
Out of these 50 cases, PD-L1 and TIL expression were seen in 16 (32%) cases and 18 (36%) cases, respectively. PD-L1 positivity was seen in 33.33% cases of grade 1 breast carcinoma, 13.79% of cases of grade 2 breast carcinoma, and in 75% case of grade 3 breast carcinoma. TILs showed positivity in 6.9% cases of grade 1 breast carcinoma, 13.79% of cases of grade 2 breast carcinoma, and in 100% cases of grade 3 breast carcinoma. Proportion of patients having PD-L1 expression was higher in grade 3 carcinoma than in grade 1 or 2. The differences were statistically significant (Chi-square value = 13.417, degree of freedom = 1, P < 0.05). The Chi-square value for TILs was 28.07, degree of freedom was 1, and P value was <0.05, which was statistically significant.
CONCLUSION
Both PD-L1 and TILs showed maximum positivity in grade 3 breast carcinoma.
论文信息
- 作者
- Mondal SK、Bhattacharya S、Sarkar AP、Saha R
- 单位
- Department of Pathology, All India Institute of Medical Science, Kalyani, West Bengal, India.India
- 期刊
- Journal of cancer research and therapeutics2023 Apr
- 原文标识
- PubMed 37147987 · DOI 10.4103/jcrt.jcrt_2013_21