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免疫治疗新前沿:靶向乳腺癌的 CAR-T (CAR-T) 细胞和巨噬细胞 (CAR-M) 治疗

英文原题:The New Frontier of Immunotherapy: Chimeric Antigen Receptor T (CAR-T) Cell and Macrophage (CAR-M) Therapy against Breast Cancer.

查看英文原题

The New Frontier of Immunotherapy: Chimeric Antigen Receptor T (CAR-T) Cell and Macrophage (CAR-M) Therapy against Breast Cancer.

PubMed 2023/03/04(内容时间) Cancers (Basel) Q2 · IF 4.8(JCR 2025)

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中文摘要

乳腺癌是最常见的肿瘤组织学类型之一。目前根据具体组织学亚型,采用包括免疫疗法在内的多种治疗策略延长患者生存。近期CAR-T 细胞疗法在血液系统肿瘤中取得惊人疗效,推动这一新型治疗策略拓展至实体瘤。本文讨论乳腺癌中基于嵌合抗原受体的免疫疗法,包括CAR-T 细胞和CAR巨噬细胞(CAR-M)疗法。

展开英文摘要原文

Breast cancer represents one of the most common tumor histologies. To date, based on the specific histotype, different therapeutic strategies, including immunotherapies, capable of prolonging survival are used. More recently, the astonishing results that were obtained from CAR-T cell therapy in haematological neoplasms led to the application of this new therapeutic strategy in solid tumors as well.

Our article will deal with chimeric antigen receptor-based immunotherapy (CAR-T cell and CAR-M therapy) in breast cancer.

论文信息

作者
Schepisi G、Gianni C、Palleschi M、Bleve S、Casadei C、Lolli C、Ridolfi L、Martinelli G
单位
IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014 Meldola, Italy.Italy
文献类型
综述
期刊
Cancers2023 Mar 4
原文标识
PubMed 36900394 · DOI 10.3390/cancers15051597