基于磁共振成像的影像组学模型预测乳腺癌中 CD8(+)TIL（肿瘤浸润淋巴细胞）的空间分布

Infiltration of CD8 + T cells and their spatial contexture, represented by immunophenotype, predict the prognosis and therapeutic response in breast cancer.

However, a non-surgical method using radiomics to evaluate breast cancer immunophenotype has not been explored.

Here, we assessed the CD8 + T cell-based immunophenotype in patients with breast cancer undergoing upfront surgery (n = 182).

We extracted radiomic features from the four phases of dynamic contrast-enhanced magnetic resonance imaging, and randomly divided the patients into training (n = 137) and validation (n = 45) cohorts. For predicting the immunophenotypes, radiomic models (RMs) that combined the four phases demonstrated superior performance to those derived from a single phase. For discriminating the inflamed tumor from the non-inflamed tumor, the feature-based combination model from the whole tumor (RM-whole FC ) showed high performance in both training (area under the receiver operating characteristic curve [AUC] = 0.

973) and validation cohorts (AUC = 0. 985). Similarly, the feature-based combination model from the peripheral tumor (RM-peri FC ) discriminated between immune-desert and excluded tumors with high performance in both training (AUC = 0. 993) and validation cohorts (AUC = 0. 984). Both RM-whole FC and RM-peri FC demonstrated good to excellent performance for every molecular subtype.

Furthermore, in patients who underwent neoadjuvant chemotherapy (n = 64), pre-treatment images showed that tumors exhibiting complete response to neoadjuvant chemotherapy had significantly higher scores from RM-whole FC and lower scores from RM-peri FC .

Our RMs predicted the immunophenotype of breast cancer based on the spatial distribution of CD8 + T cells with high accuracy. This approach can be used to stratify patients non-invasively based on the status of the tumor-immune microenvironment.