CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
利用黏膜相关恒定 T（MAIT）细胞在癌细胞治疗中的力量
英文原题：Harnessing the Power of Mucosal-Associated Invariant T (MAIT) Cells in Cancer Cell Therapy.
查看英文原题
Harnessing the Power of Mucosal-Associated Invariant T (MAIT) Cells in Cancer Cell Therapy.
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中文摘要
黏膜相关恒定T（MAIT）细胞是一种新兴的先天样T细胞，在维持免疫稳态尤其是宿主防御中发挥关键作用。尽管许多研究暗示MAIT细胞可用于肿瘤免疫，但MAIT细胞是促肿瘤还是抗肿瘤仍不明确，正如其他在肿瘤免疫中具有双重作用的先天样T细胞一样。尽管当内源性MAIT细胞作为治疗干预靶点时这一困难依然存在，但诱导多能干细胞来源的MAIT细胞（reMAIT细胞）的出现将使利用这些细胞进行免疫细胞治疗成为可能。在这篇综述中，我们将讨论MAIT细胞在肿瘤免疫中可能的作用以及reMAIT细胞治疗肿瘤的潜力。
展开英文摘要原文
Mucosal-associated invariant T (MAIT) cells, a burgeoning type of the innate-like T cells, play a crucial role in maintaining immune homeostasis, particularly in host defense. Although many studies have implied the use of MAIT cells in tumor immunity, whether MAIT cells are pro-tumor or anti-tumor has remained elusive, as in the case for other innate-like T cells that possess dichotomous roles in tumor immunity.
Although this difficulty persists where endogenous MAIT cells are the target for therapeutic intervention, the advent of induced pluripotent stem-cell-derived MAIT cells (reMAIT cells) will make it possible to harness these cells for immune cell therapy. In this review, we will discuss possible roles of MAIT cells in tumor immunity and the potential of reMAIT cells to treat tumors.
论文信息
- 作者
- Sugimoto C、Fujita H、Wakao H
- 单位
- Host Defense Division, Center for Frontier Medicines, Dokkyo Medical University, Mibu 321-0293, Japan.Japan
- 文献类型
- 综述
- 期刊
- Biomedicines2022 Dec 7
- 原文标识
- PubMed 36551916 · DOI 10.3390/biomedicines10123160
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