基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
秘鲁乳腺癌患者血液中 PIK3CA 突变与 TIL（肿瘤浸润淋巴细胞）的关联
英文原题：Association between PIK3CA Mutations in Blood and Tumor-Infiltrating Lymphocytes in Peruvian Breast Cancer Patients.
查看英文原题
Association between PIK3CA Mutations in Blood and Tumor-Infiltrating Lymphocytes in Peruvian Breast Cancer Patients.
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研究概要
在我们的秘鲁乳腺癌系列中，ctDNA 中 PIK3CA 突变的存在较为常见，与较低的 TIL 水平相关，并倾向于预测不良结局。
研究思路结论见上方概要
目的
评估秘鲁乳腺癌患者中循环肿瘤DNA（ctDNA）的存在与肿瘤特征（包括TIL（肿瘤浸润淋巴细胞）水平）之间的关系。
方法
这是一项在秘鲁国家肿瘤疾病研究所进行的前瞻性研究。我们评估了TIL水平和ctDNA中的PIK3CA突变。从患者档案中收集了临床特征，包括结局数据。生存期从采血日期计算至事件发生时间。收集的数据使用SPSS软件25版进行分析。
结果
我们分析了183例乳腺癌患者的血浆样本。大多数病例为Luminal-B型（44.8%）和II期（41.5%），中位基质TIL为30%。在35%的病例中检测到ctDNA中的PIK3CA突变（大多数为E545K），并与较低的TIL水平相关（p=0.04）。在整个系列中，ctDNA中的PIK3CA倾向于与晚期分期相关（p=0.09），在非转移性情况下与更高的复发率相关（p=0.053）。ctDNA中存在PIK3CA的患者倾向于生存期较短（p=0.083）。
展开英文摘要原文
OBJECTIVE
To evaluate the relationship between circulating tumor DNA (ctDNA) presence and tumor features including tumor-infiltrating lymphocyte (TIL) levels in Peruvian breast cancer patients.
MATERIALS AND METHODS
This was a prospective study conducted at the Instituto Nacional de Enfemedades Neoplasicas, Peru. We evaluated level of TIL and PIK3CA mutations in ctDNA. Clinical characteristics, including outcome data, were collected from the patient file. Survival was calculated from the date of blood sample drawn to the event time. Data collected were analyzed using SPSS software version 25.
RESULTS
We analyzed plasma samples from 183 breast cancer patients. most cases were of Luminal-B (44.8%) phenotype and stage II (41.5%), and median stromal TIL was 30%. PIK3CA mutation in ctDNA was detected in 35% cases (most with E545K) and was associated with lower TIL level (p=0.04). PIK3CA in ctDNA tended to be associated with advanced stages (p=0.09) in the whole series and with higher recurrence rates (p=0.053) in the non-metastatic setting. Patients with presence of PIK3CA in ctDNA tended to have shorter survival (p=0.083).
CONCLUSION
Presence of PIK3CA mutation in ctDNA was frequently found in our Peruvian breast cancer series, was associated with lower TIL levels and tended to predict poor outcomes.
论文信息
- 作者
- Castaneda CA、Castillo M、Bernabe LA、Suarez N、Romero A、Sanchez J、Torres E、Enciso J
- 单位
- Department of Medical Oncology, Instituto Nacional de Enfermedades Neoplasicas, Lima 15038, Peru.
- 期刊
- Asian Pacific journal of cancer prevention : APJCP2022 Oct 1
- 原文标识
- PubMed 36308356 · DOI 10.31557/APJCP.2022.23.10.3331
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