基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
间质 TIL（肿瘤浸润淋巴细胞）（sTILs）与印度尼西亚三阴性乳腺癌较高分级、较低分期的相关性
英文原题：Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers.
查看英文原题
Stromal Tumor Infiltrating Lymphocytes (sTILs) Were Associated with a Higher Grade and a Lower Stage of Indonesian Triple Negative Breast Cancers.
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研究概要
结果表明，sTILs 可能作为 TNBC 的额外病理参数。
研究思路结论见上方概要
目的
本研究旨在探讨sTILs与三阴性乳腺癌（TNBC）患者临床病理参数及总生存期（OS）的相关性。
方法
本研究使用了2008-2017年间从印度尼西亚日惹Sardjito总医院收集的125例TNBC患者的石蜡包埋组织。从苏木精-伊红（H&E）染色样本中检查间质TILs，并使用20%截断值将其分类为低评分或高评分。分析sTILs与临床病理参数、相对风险（RR）和OS的关联，使用95%置信区间（CI），显著性设定为p<0.05。
结果
本研究中较高比例的TNBC患者为40岁（83.3%）、高肿瘤分级（68%）、肿瘤分期>IIIa（56%）、存活（50.4%），且sTILs较低（54.4%）。结果显示，sTILs与较高的肿瘤分级或较低的肿瘤分期之间存在显著关联（分别为B = 0.259，95%CI = 0.090-0.468，p = 0.004和B = -0.255，95%CI = -0.433 - -0.080，p = 0.005）。同时，sTILs与诊断时年龄（B = 0.027，95%CI = -0.193 - 0.264，p = 0.758）或患者的3年OS（HR = 0.342，95%CI = 0.41 - 1.43，p = 0.402）无关。
展开英文摘要原文
OBJECTIVE
This study aimed to investigate the association of sTILs with clinicopathological parameters and overall survival (OS) in patients with triple negative breast cancer (TNBC).
METHODS
One hundred and twenty-five paraffin embedded tissue of patients with TNBC, collected from Dr. Sardjito General Hospital Yogyakarta, Indonesia, between 2008-2017, were used in this study. Stromal TILs were examined from hematoxylin and eosin (H&E)-stained samples, and classified as either low or high score using 20% cut-off. Analysis of the association of sTILs with clinicopathological parameters, relative risk (RR) and OS used 95% confidence interval (CI) with significance set as p<0.05.
RESULTS
The higher proportion of TNBC patients in this study were 40 years old (83.3%), high tumor grade (68%), tumor stage >IIIa (56%), alive (50.4%), and with low sTILs (54.4%). The results showed significant association between sTILs and a higher grade or a lower stage of tumor (B = 0.259, 95%CI = 0.090-0.468, p = 0.004 and B = -0.255, 95%CI = -0.433 - -0.080, p = 0.005, respectively ). Meanwhile sTILs were not associated with age at diagnosis (B = 0.027, 95%CI = -0.193 - 0.264 p = 0.758 nor 3-year OS of patients (HR = 0.342, 95%CI = 0.41 - 1.43 p = 0.402).
CONCLUSION
The results indicate that sTILs may serve as an additional pathological parameter for TNBC.
论文信息
- 作者
- Widodo I、Ghozali A、Purwanto I、Ferronika P
- 单位
- Department of Anatomic Pathology, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada, Indonesia.Indonesia
- 期刊
- Asian Pacific journal of cancer prevention : APJCP2022 Aug 1
- 原文标识
- PubMed 36037130 · DOI 10.31557/APJCP.2022.23.8.2749
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