RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
原发结直肠癌组织学与相应肝转移灶组织病理学生长模式的关系
英文原题：The relationship between primary colorectal cancer histology and the histopathological growth patterns of corresponding liver metastases.
查看英文原题
The relationship between primary colorectal cancer histology and the histopathological growth patterns of corresponding liver metastases.
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研究概要
本研究的结果将原发性结直肠癌的组织病理学与相应肝转移灶的 HGP 相关联。
中文摘要
背景
组织病理学生长模式（HGP）是结直肠癌肝转移（CRLM）的预后及疗效预测生物标志物。本研究评估HGP与原发性结直肠癌（CRC）组织病理学特征之间的关系。
方法
纳入183名未经治疗、接受CRC及CRLM切除的患者。确定13项CRC组织病理学标志物，并比较促纤维增生型与非促纤维增生型HGP，包括肿瘤左右侧、pT及pN分期、肿瘤分级、肿瘤沉积、神经周围／淋巴血管／壁外静脉侵犯、瘤周出芽、基质类型、CRC生长模式、克罗恩样淋巴反应及TIL密度。采用CRC和CRLM特征进行Logistic回归分析。
结果
在所评估的所有指标中，非促纤维增生型CRLM更常伴有不良原发CRC组织病理学特征；其中TIL密度较低、缺乏克罗恩样淋巴反应及基质“不成熟”三项差异均具有显著性（均p<0.03）。非促纤维增生型CRLM患者不良CRC组织病理学特征的累积发生数显著高于促纤维增生型，观察到的不良特征中位数（四分位距）分别为4（3～6）和2（1～3.5）（p<0.001）。纳入9项CRC组织病理学指标和2项CRLM特征的多变量回归模型具有良好鉴别效能（曲线下面积=0.83）。
结论
本研究结果显示，原发CRC组织病理学特征与对应肝转移灶HGP相关。
展开英文摘要原文
BACKGROUND
The histopathological growth patterns (HGPs) are a prognostic and predictive biomarker in colorectal cancer liver metastasis (CRLM). This study evaluates the relationship between the HGP and primary colorectal cancer (CRC) histopathology.
METHODS
A total of 183 treatment-naive patients with resected CRC and CRLM were included. Thirteen CRC histopathology markers were determined and compared between the desmoplastic and non-desmoplastic HGP; tumour sidedness, pT&pN stage, tumour grade, tumour deposits, perineural- (lympho-)vascular- and extramural venous invasion, peritumoural budding, stroma type, CRC growth pattern, Crohn's-like lymphoid reaction, and tumour-infiltrating lymphocyte (TIL) density. Logistic regression analysis was performed using both CRC and CRLM characteristics.
RESULTS
Unfavourable CRC histopathology was more frequent in non-desmoplastic CRLM for all markers evaluated, and significantly so for a lower TIL density, absent Crohn's-like lymphoid reaction, and a "non-mature" stroma (all p < 0.03). The cumulative prevalence of unfavourable CRC histopathology was significantly higher in patients with non-desmoplastic compared to desmoplastic CRLM, with a median (IQR) of 4 (3-6) vs 2 (1-3.5) unfavourable characteristics observed, respectively (p < 0.001). Multivariable regression with 9 CRC histopathology markers and 2 CRLM characteristics achieved good discriminatory performance (AUC = 0.83).
CONCLUSIONS
The results of this study associates primary CRC histopathology with the HGP of corresponding liver metastases.
论文信息
- 作者
- Höppener DJ、Stook JPL、Galjart B、Nierop PMH、Nagtegaal ID、Vermeulen PB、Grünhagen DJ、Verhoef C
- 第一作者单位
- Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands.Netherlands
- 通讯作者单位
- Department of Surgical Oncology and Gastrointestinal Surgery, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, the Netherlands. c.verhoef@erasmusmc.nl.Netherlands
- 期刊
- BMC cancer2022 Aug 22
- 原文标识
- PubMed 35996090 · DOI 10.1186/s12885-022-09994-3
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