CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗后细胞因子释放综合征期间或之后发生的严重急性心力衰竭
英文原题：Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy.
查看英文原题
Severe acute heart failure during or following cytokine release syndrome after CAR T-cell therapy.
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中文摘要
尽管嵌合抗原受体（CAR）T细胞治疗后心功能障碍的报道日益增多，其动态变化和发病机制仍缺乏充分记录。本文介绍两名CAR-T 治疗后发生重度急性心力衰竭患者的临床表现和治疗经过。两例具有若干共同特征，包括接受CAR-T 治疗时骨髓受累，以及细胞因子释放综合征（CRS）早发，患者在CAR-T 输注当天即出现发热。对于CRS早发和／或重症患者，应密切监测心力衰竭的可能性。
展开英文摘要原文
Although cardiac dysfunction after chimeric antigen receptor (CAR) T-cell therapy has been increasingly reported, the underlying dynamics and pathogenesis are not well documented.
Herein, we describe the clinical presentation and treatment for two patients who developed severe acute heart failure after CAR T-cell therapy. Both cases shared several common characteristics, including the bone marrow involvement at the time of CAR T-cell therapy and early onset of cytokine release syndrome (CRS) with fever developing on the day of CAR T-cell infusion. Patients with early onset and/or severe CRS should be carefully monitored for the possibility of heart failure.
论文信息
- 作者
- Yoshihara K、Orihara Y、Hoshiyama T、Tamaki H、Sunayama I、Matsuda I、Nishikawa A、Kumamoto T
- 单位
- Department of Hematology, Hyogo Medical University Hospital, Hyogo, Japan.Japan
- 文献类型
- 病例报告
- 期刊
- Leukemia research reports2022
- 原文标识
- PubMed 35898695 · DOI 10.1016/j.lrr.2022.100338
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →