基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
自述为非裔美国人和非非裔美国人的三阴性乳腺癌的肿瘤免疫微环境
英文原题：Tumor immune microenvironment of self-identified African American and non-African American triple negative breast cancer.
查看英文原题
Tumor immune microenvironment of self-identified African American and non-African American triple negative breast cancer.
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中文摘要
肿瘤免疫微环境的差异可能导致癌症患者预后和治疗反应的差异。我们假设，由于祖先相关或社会经济因素，非裔美国人（AA）和非AA患者之间可能存在肿瘤免疫微环境的差异，这可能部分解释临床结局的差异。我们分析了自我认定为AA和非AA患者的临床匹配三阴性乳腺癌（TNBC）组织，发现AA样本中基质TIL、PD-L1 IHC阳性、免疫相关通路的mRNA表达以及免疫治疗反应预测特征显著更高（p < 0.05；Fisher精确检验、Mann-Whitney检验、置换检验）。非AA样本中癌症生物学和代谢通路、TAM-M2和免疫排斥显著更高（p < 0.05；置换检验、Mann-Whitney检验）。体细胞肿瘤突变负荷无差异。总体而言，AA TNBC中存在更强的免疫浸润和炎症，这些差异可能影响对免疫检查点抑制剂和其他调节免疫微环境的治疗药物的反应。
展开英文摘要原文
Differences in the tumor immune microenvironment may result in differences in prognosis and response to treatment in cancer patients.
We hypothesized that differences in the tumor immune microenvironment may exist between African American (AA) and NonAA patients, due to ancestry-related or socioeconomic factors, that may partially explain differences in clinical outcomes.
We analyzed clinically matched triple-negative breast cancer (TNBC) tissues from self-identified AA and NonAA patients and found that stromal TILs, PD-L1 IHC-positivity, mRNA expression of immune-related pathways, and immunotherapy response predictive signatures were significantly higher in AA samples (p < 0.
05; Fisher's Exact Test, Mann-Whitney Test, Permutation Test). Cancer biology and metabolism pathways, TAM-M2, and Immune Exclusion were significantly higher in NonAA samples (p < 0. 05; Permutation Test, Mann-Whitney Test). There were no differences in somatic tumor mutation burden.
Overall, there is greater immune infiltration and inflammation in AA TNBC and these differences may impact response to immune checkpoint inhibitors and other therapeutic agents that modulate the immune microenvironment.
论文信息
- 作者
- Marczyk M、Qing T、O'Meara T、Yagahoobi V、Pelekanou V、Bai Y、Reisenbichler E、Cole KS
- 第一作者单位
- Department of Data Science and Engineering, Silesian University of Technology, Gliwice, Poland.Poland
- 通讯作者单位
- Yale Cancer Center, Yale University, New Haven, CT, USA. kim.blenman@yale.edu.United States
- 期刊
- NPJ breast cancer2022 Jul 22
- 原文标识
- PubMed 35869114 · DOI 10.1038/s41523-022-00449-3
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