CAR-T(CAR-T)细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Emerging advances in nanomedicine for breast cancer immunotherapy: opportunities and challenges.
Emerging advances in nanomedicine for breast cancer immunotherapy: opportunities and challenges.
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乳腺癌是全球女性癌症相关发病率和死亡率最常见的原因之一。所有癌症的早期诊断和适当的治疗方法都是获得良好预后的关键。针对乳腺癌免疫系统的治疗已成为临床现实,并取得了显著成功,特别是检查点阻断抗体和CAR-T 细胞疗法。
然而,癌症免疫疗法的临床应用中也出现了不可避免的挫折,包括由于免疫刺激剂向免疫细胞的递送不足和免疫系统调节失控而导致的免疫反应不充分。快速的进展和新的证据表明,基于纳米医学的免疫疗法可能是治疗乳腺癌的一种可行选择。始于乳腺的癌症被称为乳腺癌。它可能起源于一侧或双侧乳房。它是全球女性癌症相关死亡的主要原因之一。癌症免疫疗法是一种颠覆性的治疗方法,它提高了宿主防御系统精准识别和消灭癌细胞的能力。癌症免疫疗法,也称为免疫肿瘤学,是一种乳腺癌治疗选择,利用人体的自然防御系统来预防、调节和消灭乳腺癌。免疫疗法用于增强或改变免疫系统的功能,使其能够定位并摧毁癌细胞。了解免疫疗法的工作原理和预期效果,通常可以让患者安心,从而对治疗做出明智的决定,特别是当免疫疗法是特定患者治疗计划的一部分时。
Breast cancer is one of the most common causes of cancer-related morbidity and mortality in women worldwide. Early diagnosis and an appropriate therapeutic approach for all cancers are climacterics for a favorable prognosis. Targeting the immune system in breast cancer is already a clinical reality with notable successes, specifically with checkpoint blockade antibodies and chimeric antigen receptor T-cell therapy.
However, there have been inevitable setbacks in the clinical application of cancer immunotherapy, including inadequate immune responses due to insufficient delivery of immunostimulants to immune cells and uncontrolled immune system modulation. Rapid advancements and new evidence have suggested that nanomedicine-based immunotherapy may be a viable option for treating breast cancer. Cancer that begins in the breast is referred to as breast cancer. It may originate in either one or both breasts. It is one of the main causes of cancer-related death among women worldwide.
Cancer immunotherapy is a game-changing treatment that improves the ability of the host defense system to spot and eliminate cancer cells with pinpoint accuracy. Cancer immunotherapy, also referred to as immuno-oncology, is a type of treatment option for breast cancer that uses the body’s natural defense system to prevent, regulate and eliminate breast cancer.
Immunotherapy is used to enhance or alter the functioning of the immune system so that it can locate and destroy cancer cells. Knowing how immunotherapy works and what to anticipate can often offer peace of mind to the patient who can then make informed decisions about care, especially if immunotherapy is part of the treatment plan for a particular patient.
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