RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
结直肠癌中的免疫反应：其作为预测和预后生物标志物意义的综述
英文原题：Immune response in colorectal carcinoma: a review of its significance as a predictive and prognostic biomarker.
查看英文原题
Immune response in colorectal carcinoma: a review of its significance as a predictive and prognostic biomarker.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
中文摘要
结直肠癌是全球癌症相关死亡的主要原因。II期和III期肿瘤的预后异质性显著，需要开发新的生物标志物以更清晰地识别有疾病进展风险的患者。近年来，肿瘤免疫环境，特别是T淋巴细胞的类型和数量，已被证明是预测结直肠癌患者预后的有用生物标志物。在这篇综述中，将详细阐述免疫反应在结直肠癌中的意义，包括其对预后和治疗反应的影响。
展开英文摘要原文
Colorectal carcinoma is a leading cause of cancer-related death worldwide. There is significant prognostic heterogeneity in stages II and III tumours, necessitating the development of new biomarkers to more clearly identify patients at risk of disease progression.
Recently, the tumour immune environment, particularly the type and quantity of T lymphocytes, has been shown to be a useful biomarker in predicting prognosis for patients with colorectal carcinoma. In this review, the significance of the immune response in colorectal carcinoma, including its influence on prognosis and response to therapy, will be detailed.
论文信息
- 作者
- Bell PD、Pai RK
- 单位
- Department of Pathology, University of Pittsburgh Medical Centre, Pittsburgh, PA, USA.United States
- 文献类型
- 综述
- 期刊
- Histopathology2022 Dec
- 原文标识
- PubMed 35758208 · DOI 10.1111/his.14713