基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
乳腺癌中的免疫学与免疫治疗
英文原题：Immunology and immunotherapy in breast cancer.
查看英文原题
Immunology and immunotherapy in breast cancer.
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中文摘要
免疫肿瘤学是医学中一个快速发展的领域。药物联合治疗已在多种肿瘤类型的许多临床试验中进行了研究。近年来，针对 PD-1 及其配体 PD-L1 的单克隆抗体检查点抑制疗法已被开发出来。乳腺癌在免疫肿瘤学领域的研究相对较晚。本综述聚焦于免疫检查点抑制用于各种乳腺癌亚型根治性治疗的临床证据。此外，我们呈现了证明TIL（肿瘤浸润淋巴细胞）（CD4 和 CD8）水平的预后和预测价值、其定量比值及其与调控基因（PD-1、PD-L1 和 FOX-P3）相关性的研究结果。
展开英文摘要原文
Immuno-oncology is a rapidly developing field in medicine. Drug combination therapies have already been studied in many clinical trials on various tumor types. In recent years, a checkpoint inhibition therapy with monoclonal antibodies targeting PD-1 and its ligand PD-L1 has been developed. Breast cancer had been examined in the field of immune-oncology relatively recently. This review focuses on clinical evidence regarding immune checkpoint inhibition for curative treatment of various breast cancer subtypes.
In addition, we present the results of studies demonstrating the prognostic and predictive value of levels of tumorinfiltrating lymphocytes (CD4 and CD8), their quantitative ratios, and their correlation with regulatory genes (PD-1, PD-L1, and FOX-P3).
论文信息
- 作者
- Semiglazov V、Tseluiko A、Kudaybergenova A、Artemyeva A、Krivorotko P、Donskih R
- 单位
- Petrov National Medicine Cancer-Research Center Ministry of Health, Saint-Petersburg 197758, Russia.Russia
- 文献类型
- 综述
- 期刊
- Cancer biology & medicine2022 Jun 9
- 原文标识
- PubMed 35676750 · DOI 10.20892/j.issn.2095-3941.2021.0597
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