基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
秘鲁女性乳腺肿瘤中的人乳头瘤病毒、巨细胞病毒感染与 P16 染色
英文原题：Human Papillomavirus, Cytomegalovirus Infection and P16 Staining in Breast Tumors from Peruvian Women.
查看英文原题
Human Papillomavirus, Cytomegalovirus Infection and P16 Staining in Breast Tumors from Peruvian Women.
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研究概要
在秘鲁乳腺癌中，HCMV 感染常见，但 HR- HPV 感染少见。
中文摘要
目的
评估秘鲁乳腺癌（BC）病灶中病毒感染的分布频率及其与临床病理特征的关联。此外，前瞻性评估 p16 和TIL（肿瘤浸润淋巴细胞）水平，以开展综合分析。
方法
通过 qPCR 检测 447 份 BC 和 79 份非癌冷冻样本中的高危人乳头瘤病毒（HR-HPV）。对来自 238 例 BC 的配对石蜡样本进行人巨细胞病毒（HCMV）和 p16 免疫组化染色，并在 397 例 BC 病例中计算 TIL。
结果
HCMV 阳性率为 72.5%。HR-HPV 在 2.9% 的 BC 样本和 1.3% 的非恶性样本中检出。p16 阳性率为 28.15%，TIL 中位百分比为 30%。HR-HPV 感染与非导管组织学类型（p=0.003）及 p16 阳性（p=0.017）相关。p16 阳性与较高 T 分期（p=0.022）、分级（p=0.009）、TIL 水平（p=0.002）及三阴性表型（p=0.021）相关。
结论
HCMV 感染常见，但 HR-HPV 感染在秘鲁 BC 中并不常见。p16 阳性与 HR-HPV 感染、较高 TIL 水平及侵袭性特征相关。
展开英文摘要原文
OBJECTIVE
To evaluate the frequency distribution of viral infections in Peruvian Breast Cancer (BC) lesions and its association with clinicopathological features. Additionally, a prospective evaluation of p16 and Tumor-infiltrating lymphocytes (TIL) levels were performed for developing a comprehensive analysis.
METHODS
Detection of high risk- human papillomavirus (HR- HPV) through qPCR was performed in 447 BC and 79 non-cancer frozen samples. Paired paraffin samples from 238 BC were stained with Human cytomegalovirus (HCMV) and p16 immunohistochemistry. TIL was calculated in 397 BC cases.
RESULTS
HCMV was positive in 72.5%. HR- HPV was detected in 2.9% of BC and 1.3% of non-malignant samples. P16+ was found in 28.15% and median TIL percentage was 30. HR- HPV infection was associated with non-ductal histology (p=0.003) and p16+ (p=0.017). Positive P16+ was associated with higher T stage (p=0.022), grade (p=0.009), TIL level (p=0.002), and triple-negative phenotype (p=0.021).
CONCLUSION
HCMV is frequent, but HR- HPV infection is unusual in Peruvian BC. P16+ is associated with HR- PVH infection, high TIL and aggressive features.
论文信息
- 作者
- Calderon G、Castaneda CA、Castillo M、Sanchez J、Bernabe L、Suarez N、Tello K、Torres E
- 第一作者单位
- Department of Breast Surgery, Instituto Nacional de Enfermedades Neoplasicas, Lima, Peru.
- 通讯作者单位
- Laboratory of Oncovirology, Virology Program, Faculty of Medicine, Institute of Biomedical Sciences (ICBM), University of Chile, Santiago, Chile.
- 期刊
- Asian Pacific journal of cancer prevention : APJCP2022 May 1
- 原文标识
- PubMed 35633540 · DOI 10.31557/APJCP.2022.23.5.1571
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