PROTAC 工程化蛋白/DNA 纳米抗原是癌症免疫治疗中树突状细胞疫苗的有效增强剂
PROTAC-Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
淋巴结作为抗肿瘤免疫治疗工具：结内肿瘤特异性抗原脉冲树突状细胞疫苗免疫治疗
英文原题：Lymph Nodes as Anti-Tumor Immunotherapeutic Tools: Intranodal-Tumor-Specific Antigen-Pulsed Dendritic Cell Vaccine Immunotherapy.
查看英文原题
Lymph Nodes as Anti-Tumor Immunotherapeutic Tools: Intranodal-Tumor-Specific Antigen-Pulsed Dendritic Cell Vaccine Immunotherapy.
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中文摘要
人体内分布着数百个淋巴结（LN）。尽管每个淋巴结体积较小，却是完整的免疫器官，含有几乎所有类型的免疫活性细胞及作为支架的基质细胞。本综述强调淋巴结在癌症免疫治疗中的重要性。首先，回顾淋巴结作为抗肿瘤免疫发生场所的结构与功能特征，并讨论其在肿瘤免疫治疗中的应用价值。其次，探讨超声引导下淋巴结内注射方法的理论依据和背景。此外，综述向淋巴结内给予肿瘤特异性抗原负载成熟树突状细胞（DC）的治疗，包括新抗原负载疫苗。
展开英文摘要原文
Hundreds of lymph nodes (LNs) are scattered throughout the body. Although each LN is small, it represents a complete immune organ that contains almost all types of immunocompetent and stromal cells functioning as scaffolds. In this review, we highlight the importance of LNs in cancer immunotherapy.
First, we review recent reports on structural and functional properties of LNs as sites for antitumor immunity and discuss their therapeutic utility in tumor immunotherapy. Second, we discuss the rationale and background of ultrasound (US)-guided intranodal injection methods.
In addition, we review intranodal administration therapy of tumor-specific-antigen-pulsed matured dendritic cells (DCs), including neoantigen-pulsed vaccines.
论文信息
- 作者
- Morisaki T、Morisaki T、Kubo M、Morisaki S、Nakamura Y、Onishi H
- 第一作者单位
- Fukuoka General Cancer Clinic, Fukuoka 812-0018, Japan.Japan
- 通讯作者单位
- Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University; Fukuoka 812-8582, Japan.Japan
- 文献类型
- 综述
- 期刊
- Cancers2022 May 15
- 原文标识
- PubMed 35626042 · DOI 10.3390/cancers14102438
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