基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
数量与质量：乳腺癌过继性细胞疗法成功的关键
英文原题：Quantity versus quality: Keys to adoptive cell therapy success in breast cancer.
查看英文原题
Quantity versus quality: Keys to adoptive cell therapy success in breast cancer.
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中文摘要
几十年来，关于自体TIL（肿瘤浸润淋巴细胞）在治疗难治性肿瘤中诱导部分甚至完全缓解的报道，推动了对此过程进行优化和改进的方法研究。Zacharias 等 1 报告了一项 II 期研究的结果，该研究在转移性乳腺癌患者中使用新抗原反应性 TIL，观察到两例部分缓解和一例完全缓解。
展开英文摘要原文
Over decades, reports of autologous tumor-infiltrating lymphocytes inducing partial and even complete responses in treatment-refractory tumors has spurred investigation into methods for refining and improving this process. Zacharias et al. 1 report two partial and one complete response from a phase II study utilizing neoantigen-reactive TILs in patients with metastatic breast cancer.
论文信息
- 作者
- Lou E
- 单位
- Masonic Cancer Center and Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: emil-lou@umn.edu.United States
- 文献类型
- 评论
- 期刊
- Med (New York, N.Y.)2022 Apr 8
- 原文标识
- PubMed 35590150 · DOI 10.1016/j.medj.2022.03.007