RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
细胞因子诱导的杀伤细胞在结直肠癌治疗中介导的通路
英文原题：Cytokine-induced killer cells mediated pathways in the treatment of colorectal cancer.
查看英文原题
Cytokine-induced killer cells mediated pathways in the treatment of colorectal cancer.
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中文摘要
细胞因子诱导的杀伤（CIK）细胞疗法是一种过继性免疫疗法，由于其高增殖率和抗肿瘤特性，正在被研究用于治疗多种实体瘤。由于晚期结直肠癌（CRC）死亡率高、生存率低，且化疗和放疗在治疗中的疗效有限，CIK细胞疗法在CRC中的应用已在大量研究中得到评估。本综述旨在总结已开展的关于CIK细胞疗法在CRC中安全性和临床疗效的临床研究。因此，本综述纳入了临床试验中1,969例入组CRC患者，其中842例患者接受了CIK细胞联合化疗并联合或不联合树突状细胞（DC）输注。此外，还讨论了CIK细胞疗法涉及的信号通路以及提高迁移能力的新方法。视频摘要。
展开英文摘要原文
Cytokine-induced killer (CIK) cell therapy is a type of adoptive immunotherapy that due to its high proliferation rate and anti-tumor characteristics, is being investigated to treat various solid tumors.
Since advanced colorectal cancer (CRC) has high mortality and poor survival rates, and the efficacy of chemotherapy and radiotherapy is limited in treatment, the application of CIK cell therapy in CRC has been evaluated in numerous studies. This review aims to summarize the clinical studies that investigated the safety and clinical efficacy of CIK cell therapy in CRC.
Therefore, 1,969 enrolled CRC patients in the clinical trials, of which 842 patients received CIK cells in combination with chemotherapy with or without dendritic cell (DC) infusions, were included in the present review.
Furthermore, the signaling pathways involved in CIK cell therapy and novel methods for improving migration abilities are discussed. Video abstract.
论文信息
- 作者
- Fayyaz F、Yazdanpanah N、Rezaei N
- 第一作者单位
- Students' Research Committee, Alborz University of Medical Sciences, Alborz, Iran.Iran
- 通讯作者单位
- Research Center for Immunodeficiencies, Children's Medical Center Hospital, Tehran University of Medical, Dr. Qarib St, Keshavarz Blvd, Tehran, 14194, Iran. rezaei_nima@tums.ac.ir.Iran
- 文献类型
- 综述 · 音视频资料
- 期刊
- Cell communication and signaling : CCS2022 Mar 28
- 原文标识
- PubMed 35346234 · DOI 10.1186/s12964-022-00836-0
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