CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
实体瘤中 CAR-T 细胞的散在播种增强抗肿瘤疗效
英文原题：Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy.
查看英文原题
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy.
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中文摘要
CAR-T 细胞疗法是治疗复发/难治性B细胞恶性肿瘤的里程碑。然而，CAR-T 细胞尚未在实体瘤中取得有益效果。在此，我们实现了一种多孔微针贴片，其可容纳CAR-T 细胞，并在植入肿瘤床或术后切除腔时，允许通过原位穿透介导的CAR-T 细胞播种。加载在微针尖端孔隙中的CAR-T 细胞被轻易地以均匀散布的方式护送至肿瘤，且不丧失其活性。与直接瘤内注射相比，这种微针介导的局部递送增强了CAR-T 细胞的浸润和免疫刺激。这种可定制的贴片为活细胞散布播种以治疗多种肿瘤提供了一个变革性平台。
展开英文摘要原文
Chimeric antigen receptor T cell (CAR T) therapy was a milestone in the treatment of relapsed and refractory B cell malignancies.
However, beneficial effects of CAR T cells have not been obtained in solid tumors yet.
Herein, we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity.
Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors.
论文信息
- 作者
- Li H、Wang Z、Ogunnaike EA、Wu Q、Chen G、Hu Q、Ci T、Chen Z
- 单位
- College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.China
- 期刊
- National science review2022 Mar
- 原文标识
- PubMed 35265340 · DOI 10.1093/nsr/nwab172
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