基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
三阴性乳腺癌肿瘤微环境的特征
英文原题：The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer.
查看英文原题
The Characteristics of Tumor Microenvironment in Triple Negative Breast Cancer.
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中文摘要
三阴性乳腺癌（TNBC）是乳腺癌的一种特殊亚型，占乳腺癌的10-20%，具有高度内在异质性。其独特的免疫微环境，包括血管内皮生长因子的高表达、TIL（肿瘤浸润淋巴细胞）（TILs）、肿瘤相关巨噬细胞（TAMs）以及其他促进肿瘤细胞生长和迁移的分子，已被证实在TNBC的发生、生长和转移中发挥双重作用。了解TNBC微环境对TNBC的预后和治疗具有重要意义。本文描述了TNBC微环境中免疫细胞的组成和功能，并总结了TNBC微环境中的主要细胞因子生长因子和趋化因子。最后，我们讨论了TNBC、细胞因子诱导的杀伤细胞治疗和免疫检查点治疗的研究进展。
展开英文摘要原文
Triple-negative breast cancer (TNBC) is a special subtype of breast cancer, accounting for 10-20% of breast cancers with high intrinsic heterogeneity. Its unique immune microenvironment, including high expression of vascular endothelial growth factors, tumor infiltrating lymphocytes (TILs), tumor-associated macrophages (TAMs), and other molecules that promote the growth and migration of tumor cells, has been shown to play a dual role in the occurrence, growth, and metastasis of TNBC.
Understanding the TNBC microenvironment is of great significance for the prognosis and treatment of TNBC. In this article, we describe the composition and function of immune cells in the TNBC microenvironment and summarize the major cytokine growth factors and chemokines in the TNBC microenvironment.
Finally, we discuss the progress of TNBC, cytokine-induced killer cell therapy, and immune checkpoint therapy.
论文信息
- 作者
- Fan Y、He S
- 单位
- Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, People's Republic of China.China
- 文献类型
- 综述
- 期刊
- Cancer management and research2022
- 原文标识
- PubMed 35018117 · DOI 10.2147/CMAR.S316700
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