CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
T 细胞衔接免疫治疗，聚焦嵌合抗原受体 (CAR) T 细胞治疗
英文原题：T Cell Engaging Immunotherapies, Highlighting Chimeric Antigen Receptor (CAR) T Cell Therapy.
查看英文原题
T Cell Engaging Immunotherapies, Highlighting Chimeric Antigen Receptor (CAR) T Cell Therapy.
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中文摘要
过去十年，嵌合抗原受体（CAR）T细胞技术彻底改变了癌症免疫治疗。该策略利用合成CAR重定向患者自身免疫细胞，使其识别肿瘤细胞表面特定抗原。抗CD19 CAR-T 细胞治疗B细胞恶性肿瘤取得前所未有的成功，并于2017年获美国食品药品监督管理局（FDA）批准。然而，广泛应用CAR-T 细胞疗法仍有重大科学挑战待解决，包括严重毒性、治疗实体瘤疗效有限，以及肿瘤恶劣微环境中的免疫抑制。此外，CAR-T 细胞疗法属于个体化医疗，生产耗时且资源密集，因此费用非常高。上述因素推动研究者创新工程化策略，开发抗肿瘤活性更强的新型CAR-T 细胞。本文综述相关进展。
展开英文摘要原文
In the past decade, chimeric antigen receptor (CAR) T cell technology has revolutionized cancer immunotherapy. This strategy uses synthetic CARs to redirect the patient's own immune cells to recognize specific antigens expressed on the surface of tumor cells. The unprecedented success of anti-CD19 CAR T cell therapy against B cell malignancies has resulted in its approval by the US Food and Drug Administration (FDA) in 2017.
However, major scientific challenges still remain to be addressed for the broad use of CAR T cell therapy. These include severe toxicities, limited efficacy against solid tumors, and immune suppression in the hostile tumor microenvironment.
Furthermore, CAR T cell therapy is a personalized medicine of which the production is time- and resource-intensive, which makes it very expensive. All these factors drive new innovations to engineer more powerful CAR T cells with improved antitumor activity, which are reviewed in this manuscript.
论文信息
- 作者
- De Bousser E、Callewaert N、Festjens N
- 单位
- Vlaams Instituut voor Biotechnologie (VIB)-UGent Center for Medical Biotechnology, Technologiepark-Zwijnaarde 75, 9052 Ghent, Belgium.Belgium
- 文献类型
- 综述
- 期刊
- Cancers2021 Dec 1
- 原文标识
- PubMed 34885176 · DOI 10.3390/cancers13236067
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