CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
CAR-T 细胞治疗与重症监护：医疗急救团队的生存指南
英文原题：CAR T-cell therapy and critical care : A survival guide for medical emergency teams.
查看英文原题
CAR T-cell therapy and critical care : A survival guide for medical emergency teams.
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中文摘要
嵌合抗原受体（CAR）T细胞经过基因工程改造，使T细胞能够攻击特定的癌细胞，并改善难治/复发性侵袭性B细胞恶性肿瘤患者的结局。迄今为止，已有几种CAR-T 细胞产品获批，其他具有类似适应症或扩展至其他恶性肿瘤的产品目前正在评估中。CAR-T 细胞治疗的副作用可能是严重甚至危及生命的免疫相关毒性，特别是细胞因子释放综合征（CRS）和免疫效应细胞相关神经毒性综合征（ICANS）。因此，医疗急救团队（MET）越来越多地参与CAR-T 细胞接受者的评估和管理。本文描述了CAR-T 细胞治疗的原理，并总结了主要并发症及相应的治疗干预措施，旨在为MET提供一份生存指南，并提出管理算法。
展开英文摘要原文
Chimeric antigen receptor (CAR) T cells are genetically engineered to give T cells the ability to attack specific cancer cells, and to improve outcome of patients with refractory/relapsed aggressive B cell malignancies. To date, several CAR T cell products are approved and additional products with similar indication or extended to other malignancies are currently being evaluated.
Side effects of CAR T cell treatment are potentially severe or even life-threatening immune-related toxicities, specifically cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS).
Consequently, medical emergency teams (MET) are increasingly involved in the assessment and management of CAR T cell recipients. This article describes the principles of CAR T cell therapy and summarizes the main complications and subsequent therapeutic interventions aiming to provide a survival guide for METs with a proposed management algorithm.
论文信息
- 作者
- Messmer AS、Que YA、Schankin C、Banz Y、Bacher U、Novak U、Pabst T
- 单位
- Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland. anna.messmer@insel.ch.Switzerland
- 文献类型
- 综述
- 期刊
- Wiener klinische Wochenschrift2021 Dec
- 原文标识
- PubMed 34613477 · DOI 10.1007/s00508-021-01948-2
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