TP53 缺失通过上调 NF-κB-IFN-β-MHC-Ia 信号促进骨肉瘤对 NK 细胞的抵抗
TP53 Loss Elevates NF-κB-IFN-β-MHC-Ia Signaling to Promote NK Cell Resistance in Osteosarcoma.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
间充质干细胞：从生物学到治疗
英文原题：Mesenchymal stem cells from biology to therapy.
查看英文原题
Mesenchymal stem cells from biology to therapy.
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中文摘要
间充质干细胞既令人着迷，也充满未知。它们似乎能够执行广泛的功能，涉及骨骼生物学、免疫学和血液学。作为治疗手段，间充质干细胞乃至其分泌产物，都可用于再生因损伤或疾病而丢失的组织，并抑制有害的免疫反应。然而，这些细胞缺乏独特标志物，难以识别并分离为纯细胞群；实验室培养时通常采用基础且未明确界定的培养条件。甚至连它们的名称，我们也无法达成一致。间充质干细胞或许不像其他更受瞩目的干细胞那样，具备清晰的发展生物学认识和明确的分化层级，但它们提出了一个引人入胜的科学挑战。深入理解间充质干细胞生物学，将使我们能够充分利用这一临床价值极高的细胞来源。
展开英文摘要原文
Mesenchymal stem cells are as fascinating as they are enigmatic. They appear capable of performing a wide array of functions that cross skeletal biology, immunology and haematology. As therapeutics, mesenchymal stem cells or even just their secreted products may be used to regenerate tissue lost through injury or disease and suppress damaging immune reactions.
However, these cells lack unique markers and are hard to identify and isolate as pure cell populations. They are often grown in laboratories using basic and undefined culture conditions.
We cannot even agree on their name. While mesenchymal stem cells may lack the developmental understanding and defined differentiation hierarchies of their more illustrious stem cell cousins, they offer a compelling scientific challenge. In depth understanding of mesenchymal stem cell biology will enable us to exploit fully one of the most clinically valuable cell sources.
论文信息
- 作者
- Kuntin D、Genever P
- 单位
- Department of Biology, University of York, York YO10 5DD, U.K.United Kingdom
- 文献类型
- 非美国政府资助研究
- 期刊
- Emerging topics in life sciences2021 Oct 29
- 原文标识
- PubMed 34355761 · DOI 10.1042/ETLS20200303
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