基于 DNA 超分子水凝胶的保护性 NK 细胞储库用于增强三阴性乳腺癌治疗
Protective NK Cell Reservoir Based on DNA Supramolecular Hydrogel for Enhanced Triple-Negative Breast Cancer Therapy.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
双膦酸盐相关的眼部副作用：病例系列及文献综述
英文原题：Bisphosphonates Related Ocular Side Effects: A Case Series and Review of Literature.
查看英文原题
Bisphosphonates Related Ocular Side Effects: A Case Series and Review of Literature.
分数与星级只用于站内排序 —— 不代表疗效、安全性或个人适用性。
研究概要
BROSE 是双膦酸盐治疗中一种不常见的并发症，在具有自身免疫易感性的患者中发生更为频繁。
研究思路结论见上方概要
目的
描述双膦酸盐相关眼部副作用（BROSE）患者的临床特征。
方法
回顾了2009年1月至2019年12月期间所有BROSE患者的医疗记录。
结果
共识别出9例BROSE病例。所有受试者均为女性。诊断时中位年龄为69岁。双膦酸盐治疗的主要适应证为骨质疏松症（n=7）、Paget骨病（n=1）和乳腺癌（n=1）。6例（66.67%）患者表现为葡萄膜炎，1例（11%）为巩膜外层炎，2例（22%）为眼眶炎症。5起事件（55.5%）发生在开始双膦酸盐治疗后10天内，其余（44.44%）在2周至3年后发生。4例（44.44%）患者合并甲状腺疾病。发现潜在甲状腺疾病或自身免疫之间存在关联。
展开英文摘要原文
OBJECTIVE
To describe the clinical features of patients with bisphosphonate related ocular side effects (BROSE).
METHODS
The medical records of all patients with BROSE between January 2009 and December 2019 were reviewed.
RESULTS
Nine cases with BROSE were identified. All subjects were female. Median age at diagnosis was of 69 years. The leading indication for bisphosphonate treatment was osteoporosis (n=7), Paget's disease of bone (n=1) and breast cancer (n=1). Six (66.67%) patients presented with uveitis, one (11%) episcleritis and two (22%) with orbital inflammation. Five events (55.5%) occurred within 10 days of initiating the bisphosphonate and the rest (44.44%) developed within 2 weeks to 3 years later. Four (44.44%) patients had concurrent thyroid disease. An association was found between underlying thyroid disease or autoimmunity.
CONCLUSION
BROSE is an uncommon complication of bisphosphonate therapy occurring more frequently in patients with an autoimmune predisposition.
论文信息
- 作者
- Gendelman O、Tripto-Shkolnik L、Vered I、Lidar M
- 单位
- Rheumatology Unit, Sheba Medical Center, Tel Hashomer, Israel.Israel
- 文献类型
- 综述
- 期刊
- Ocular immunology and inflammation2022 Oct-Nov
- 原文标识
- PubMed 34014797 · DOI 10.1080/09273948.2021.1922705