RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
诱导多能干细胞衍生的 NK 细胞经基因修饰以表达靶向实体瘤的嵌合抗原受体
英文原题：Induced pluripotent stem cell-derived natural killer cells gene-modified to express chimeric antigen receptor-targeting solid tumors.
查看英文原题
Induced pluripotent stem cell-derived natural killer cells gene-modified to express chimeric antigen receptor-targeting solid tumors.
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中文摘要
异基因多能干细胞来源免疫细胞用于肿瘤免疫治疗已成为近期研究的热点，包括临床试验。使用多能干细胞作为异基因免疫细胞的来源，有利于对最终产品在疗效、安全性和可生产性方面进行严格的质量控制。在本综述中，我们描述了来自多种细胞来源（包括多能干细胞）的自然杀伤（NK）细胞的特征、这些NK细胞的嵌合抗原受体（CAR）修饰方法和策略，以及CAR修饰的诱导多能干细胞来源NK细胞的当前和计划中的临床试验。
展开英文摘要原文
The use of allogeneic, pluripotent stem cell-derived immune cells for cancer immunotherapy has been the subject of recent research, including clinical trials. The use of pluripotent stem cells as the source for allogeneic immune cells facilitates stringent quality control of the final product, regarding efficacy, safety, and producibility.
In this review, we have described the characteristics of natural killer (NK) cells from multiple cell sources, including pluripotent stem cells, the chimeric antigen receptor (CAR)-modification method and strategy for these NK cells, and the current and planned clinical trials of CAR-modified induced pluripotent stem cell-derived NK cells.
论文信息
- 作者
- Ueda T、Kaneko S
- 第一作者单位
- Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, CiRA, Kyoto University, Kyoto, Japan.Japan
- 通讯作者单位
- Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, CiRA, Kyoto University, Kyoto, Japan. kaneko.shin@cira.kyoto-u.ac.jp.Japan
- 文献类型
- 综述
- 期刊
- International journal of hematology2021 Nov
- 原文标识
- PubMed 32705572 · DOI 10.1007/s12185-020-02951-5