靶向 MUC1 和 PSCA 的串联 CAR-T 细胞联合抗 PD-1 抗体对非小细胞肺癌表现出强效临床前活性

Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer.

嵌合抗原受体（CAR）-T 细胞在治疗实体瘤时面临诸多问题，包括肿瘤抗原异质性和免疫抑制。