决定异体 CAR T 细胞排斥与扩增的细胞和分子机制
Cellular and molecular mechanisms determining allogeneic CAR T cell rejection and expansion.
DISEASE HUB
FOR TREATMENT
现在就能报名的(招募中)排在最前,共 4 项。同一状态内中国中心优先。信息来自 ClinicalTrials.gov 与 CDE 公开登记。能否入组、费用与可及性,以登记原文和主治医生判断为准。
FOR RESEARCH
Cellular and molecular mechanisms determining allogeneic CAR T cell rejection and expansion.
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
Endogenous CD28 Drives the Persistent Activity of CAR T Cells in Myeloma and Lymphoma Models.
Enhanced antitumoral activity of the academic CAR-T ARI0002h against normal and low BCMA-expressing myeloma cells after incorporating a transmembrane
将 CD28-TMD 整合到 ARI0002h CAR 中可增强肿瘤控制,即使在靶抗原下调的复发模型中也是如此,从而提供更好的长期疾病管理。该修饰增强了对 BCMA 表达正常和降低的 MM 肿瘤细胞系的效力,表现出更优的代谢耐力和体内活性。
CXCR4-modification enhances CAR-T efficacy by improving tumor tracking and bone marrow homing in B-cell malignancies.
BAFF-based trifunctional T-cell engagers trigger robust tumor immunity against B-cell malignancies.
Bendamustine-based lymphodepletion prior to CAR T-cell therapy: a systematic review.
Facts and Hopes: CAR T-Cell Therapy and Immune Contexture in Non-Hodgkin Lymphoma.
Targeted Therapy of CAR+ T-Cell Lymphoma after Anti-BCMA CAR T-Cell Therapy.
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