下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
ALL SOURCES
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Role of Fcγ receptors in HER2-targeted breast cancer therapy.
几种治疗性单克隆抗体(mAbs),包括靶向表皮生长因子受体、人表皮生长因子受体2(HER2)和CD20的抗体,在其作用机制中均介导片段结晶γ受体(FcγR)依赖性活动。
Integrating In Situ Immune Expression Landscape with Gene Expression-Based Subtyping to Characterize Breast Cancer Heterogeneity.
这些发现证实,部分 luminal 型肿瘤具有炎症性或巨噬细胞驱动的免疫微环境。
Immune environment of high-TIL breast cancer: triple negative and hormone receptor positive HER2 negative.
高 TIL 的三阴性乳腺癌(TNBC)与 HR⁺HER2⁻ 乳腺癌(BC)中 IC 的组成和空间分布存在显著差异,并受 PD-L1 状态影响。
Pathological response and predictive role of tumour-infiltrating lymphocytes in HER2-positive early breast cancer treated with neoadjuvant pyrotinib p
新辅助吡咯替尼联合曲妥珠单抗为基础的化疗在人类表皮生长因子受体2阳性早期BC患者中显示出有前景的疗效和可控的毒性,因此有必要开展3期试验。我们的发现也有助于理解免疫微环境在新辅助吡咯替尼为基础的治疗反应中的潜在作用。
Updated Clinical Perspectives and Challenges of Chimeric Antigen Receptor-T Cell Therapy in Colorectal Cancer and Invasive Breast Cancer.
近年来,结直肠癌(CRC)和乳腺癌(BC)的发病率在全球范围内上升,并因缺乏选择性抗肿瘤疗法而导致更高的死亡率。
Relationship between Aldehyde Dehydrogenase, PD-L1 and Tumor-Infiltrating Lymphocytes with Pathologic Response and Survival in Breast Cancer.
共分析75例患者(42.7%为TN肿瘤,57.3%为HER2+肿瘤)。
The Impact of Tumor Infiltrating Lymphocytes Densities and Ki67 Index on Residual Breast Cancer Burden following Neoadjuvant Chemotherapy.
选取153例乳腺癌病例,根据其分子亚型分为:三阴性亚型(77例)和luminal、HER2-ve亚型(76例)。
Characterization of the Immune Microenvironment in Inflammatory Breast Cancer Using Multiplex Immunofluorescence.
这些结果揭示了IBC中免疫细胞亚型分布的复杂独特模式,并为详细描述控制IBC免疫景观形成的分子通路及免疫治疗潜力提供了重要基础。
共 9 条
MEMBER ACCOUNT
登录成功会直接打开下一页。