CELL INTELLIGENCE · 肿瘤细胞治疗研究

自相残杀效应降低的人源化 CD70 靶向 CAR-T 细胞对 AML 与 RCC 表现出强效抗肿瘤活性

Humanized CD70-targeted CAR-T cells with reduced fratricide demonstrate potent antitumor activity against AML and RCC.

急性髓系白血病双特异性抗体：从骨髓免疫龛到临床转化

Bispecific Antibodies for Acute Myeloid Leukemia: From Bone Marrow Immune Niche to Clinical Translation.

寻找 AML 中安全有效的 CAR-T 靶点

The search for safe and effective CAR-T targets in AML.

面向血液肿瘤与实体瘤免疫治疗的高效、无自相残杀的非病毒工程化 CD70 靶向 CAR NK 细胞

Efficient, fratricide free non-viral engineering of CD70-targeted CAR NK cells for hematologic and solid tumor immunotherapy.

CAR-T 与 CAR NK 细胞治疗急性髓系白血病的最新进展

Recent advances in CAR T and CAR NK cell therapy for AML.

将去甲基化药物与现货型 CD70 靶向嵌合抗原受体工程化自然杀伤 T 细胞协同用于治疗急性髓系白血病

Synergizing hypomethylating agents with off-the-shelf CD70-targeted chimeric antigen receptor-engineered natural killer T cells for the treatment of a

TNF-α和 IFN-γ差异性调节 AML 细胞对 CD70 抗体介导的细胞毒性的敏感性

TNF-α and IFN-γ differentially regulate AML cell susceptibility to CD70-antibody-mediated cytotoxicity.

CD70 是 AML 中 NK 细胞免疫治疗的一个有前景的靶点。然而，AML 细胞上 HLA 分子的 IFN-γ依赖性上调导致对 ADCC 的耐药。这些发现强调了在临床试验中需要合理的联合策略来克服这种可诱导的免疫逃逸机制。

急性髓系白血病 CAR-T 细胞治疗的新兴策略：通过双抗原靶向克服异质性并提高安全性

Emerging strategies in CAR-T cell therapy for acute myeloid leukemia: overcoming heterogeneity and improving safety through dual-antigen targeting.

靶向 CD70 的 CAR-T/NK 治疗：原理、进展和未来方向

CD70-targeted CAR-T/NK therapy: Rationale, advances, and future directions.

靶向 CD70 与活化整合素 β2 的双顺反子 CAR-T 细胞克服急性髓系白血病中的抗原异质性并保持安全性

Bicistronic CAR T-cells Against CD70 & Active Integrin β2 Overcome Antigen Heterogeneity and Preserve Safety in Acute Myeloid Leukemia.