CELL INTELLIGENCE · 肿瘤细胞治疗研究

AML/MDS 细胞治疗的最新进展

Recent advances in cell therapy for AML/MDS.

异基因移植后急性髓系白血病复发中重编程失败的移植物抗白血病免疫的研究进展

Progress in reprogramming failed graft-versus-leukemia immunity in acute myeloid leukemia relapse after allogeneic transplantation.

分泌抗 CD73 scFv 的增强型 CD33 CAR-NK 细胞克服腺苷介导的免疫抑制并提高抗 AML 疗效

Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy.

CD33-CD73 双靶向 CAR-NK 平台协同靶向 AML 细胞和富含腺苷的肿瘤微环境，展现出更优的抗白血病疗效。

超越耗竭：用于血液肿瘤下一代免疫治疗的 T 细胞适应性

Beyond exhaustion: T cell fitness for next generation of immunotherapy for hematological cancer.

多组学指导的白血病动态精准医学：整合基因型、细胞状态、骨髓病理与免疫生态系统的以 AML 为中心的框架

Multi-omics-guided dynamic precision medicine in leukemia: An AML-centered framework integrating genotype, cellular state, bone marrow pathology, and

单细胞 RNA 测序揭示急性髓系白血病肿瘤微环境的免疫异质性

Single-cell RNA sequencing reveals immunological heterogeneity of the tumor microenvironment in acute myeloid leukemia.

本研究强调了 AML 微环境中的细胞异质性及复杂的免疫相互作用，为理解免疫逃逸提供了见解，并为未来的免疫治疗及靶向治疗策略提供了依据。

探索 CAR-T 之外的 CAR 细胞疗法用于髓系恶性肿瘤

Exploring CAR cell therapies beyond CAR-T for myeloid malignancies.

面向血液肿瘤与实体瘤免疫治疗的高效、无自相残杀的非病毒工程化 CD70 靶向 CAR NK 细胞

Efficient, fratricide free non-viral engineering of CD70-targeted CAR NK cells for hematologic and solid tumor immunotherapy.

CAR-T 与 CAR NK 细胞治疗急性髓系白血病的最新进展

Recent advances in CAR T and CAR NK cell therapy for AML.

通过 mRNA-LNP 工程化 CLL-1 CAR-NK 细胞以获得强效抗肿瘤活性并逆转急性髓系白血病中 HLA-E 介导的耐药

Engineering CLL-1 CAR-NK cells via mRNA-LNP for potent antitumor activity and reversal of HLA-E-mediated resistance in acute myeloid leukemia.

瞬时、非整合的 mRNA LNP 转染的 CLL-1 CAR-NK 细胞为 MDR AML 提供了一种安全有效的策略。