下一代基于抗体的癌症治疗:抗体-药物偶联物和双特异性抗体在血液系统恶性肿瘤和实体瘤中的应用
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
FRONTIER PAPERS
Next-generation antibody-based therapeutics in cancer: antibody-drug conjugates bispecific antibodies across hematologic malignancies and solid tumors
肿瘤学的治疗范式正在经历由抗体药物偶联物(ADC)和双特异性抗体(bsAb)驱动的深刻变革。
Targeting PIM2 improves antitumor immunity through promoting effector function and persistence of CD8 T cells.
PIM 激酶家族在肿瘤发生中起关键作用,但其在原代 T 细胞中的作用研究不足。
Cancer-derived extracellular vesicles in natural killer cell immune evasion: Molecular mechanisms and therapeutic insights.
NK 细胞是先天淋巴细胞,具备快速识别和消灭癌细胞的能力。
Go to the scene: T(H)9 cells superior migration ability to the lungs explains their exceptional anticancer efficacy.
过去13年的这些发现支持了TH9细胞在癌症过继治疗中的临床评估。
Second primary malignancies following CAR T-cell therapy in patients with hematologic malignancies.
我们回顾性分析了 2016 年至 2022 年在俄亥俄州立大学接受 CAR-T 治疗的 246 例 R/R B 细胞淋巴瘤(n = 228)和多发性骨髓瘤(n = 18)患者,随访至少 2 年。
RORing CAR T Cells in Solid and Hematologic Cancers: Same but Different.
最近一项 I 期临床研究在慢性淋巴细胞白血病、非小细胞肺癌和三阴性乳腺癌患者中测试了抗 ROR1 嵌合抗原受体(CAR)T 细胞。
Phase I Study of ROR1-Specific CAR-T Cells in Advanced Hematopoietic and Epithelial Malignancies.
ROR1 CAR-T 细胞在大多数患者中耐受良好。
Improved Efficacy of Triple-Negative Breast Cancer Immunotherapy via Hydrogel-Based Co-Delivery of CAR-T Cells and Mitophagy Agonist.
渗漏且结构异常的血管以及肿瘤间质内压力升高,会减少 CAR-T 细胞在包括三阴性乳腺癌(TNBC)在内的实体瘤中的浸润。
Parallel processing of T cells and natural killer cells to enhance in vivoCAR T cell activity against blood and solid cancers.
本研究鼓励优化利用白细胞单采产物。通过将废弃的PBMC回收为NK细胞,可有效增强CAR T细胞疗法,改善肿瘤清除率和生存率。
Prognostic and Predictive Value of Immune-Related Gene Expression Signatures vs Tumor-Infiltrating Lymphocytes in Early-Stage ERBB2/HER2-Positive Brea
本研究结果表明,多个B细胞相关特征与pCR和EFS的关联比主要代表T细胞的TILs更强。当同时具备TILs和基因表达数据时,免疫相关特征的预后价值似乎更优。
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