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RORing CAR T 细胞在实体瘤与血液肿瘤中:相同却不同

英文原题:RORing CAR T Cells in Solid and Hematologic Cancers: Same but Different.

PubMed 2025/02/03(内容时间) Clin Cancer Res Q1 · IF 10.9(JCR 2025)

研究概要

最近一项 I 期临床研究在慢性淋巴细胞白血病、非小细胞肺癌和三阴性乳腺癌患者中测试了抗 ROR1 嵌合抗原受体(CAR)T 细胞。

中文摘要

近期一项I期临床研究在慢性淋巴细胞白血病、非小细胞肺癌和三阴性乳腺癌患者中测试了抗ROR1嵌合抗原受体(CAR)T细胞。该产品可安全给药,在慢性淋巴细胞白血病中显示活性,但在非小细胞肺癌和三阴性乳腺癌中的活性较低。详见Jaeger-Ruckstuhl等人相关文章,第503页。

展开英文摘要原文

A recent phase I clinical study tested anti-ROR1 chimeric antigen receptor (CAR) T cells in patients with chronic lymphocytic leukemia, non-small cell lung cancer, and triple-negative breast cancer. The product could be safely administered and had activity in chronic lymphocytic leukemia but less so in non-small cell lung cancer and triple-negative breast cancer. See related article by Jaeger-Ruckstuhl et al., p. 503.

论文信息

作者
Kobold S
单位
Division of Clinical Pharmacology, LMU University Hospital, LMU Munich, Munich, Germany.Germany
期刊
Clinical cancer research : an official journal of the American Association for Cancer Research2025 Feb 3
原文标识
PubMed 39625823 · DOI 10.1158/1078-0432.CCR-24-3688