CELL INTELLIGENCE · 肿瘤细胞治疗研究

通往体内 CAR-T 成功之路：有前景的病毒载体与非病毒载体比较

On the road to in vivo CAR-T success: Comparing promising viral and non-viral vectors.

CAR mRNA 工程化 T 细胞与巨噬细胞在清除 CD19⁺ 白血病细胞中的不同效应功能与协同作用

Distinct effector functions and synergy of CAR mRNA-engineered T cells and macrophages in the clearance of CD19(+) leukemia cells.

我们的研究结果凸显了 CAR-T 细胞优越的肿瘤细胞杀伤能力。

工程化 IL-33 mRNA 的自分泌活性增强过继性 T 细胞疗法对癌性腹膜炎的疗效并与 IL-12 mRNA 协同

Autocrine activity of engineered IL-33 mRNA enhances adoptive T-cell therapy for peritoneal carcinomatosis and synergizes with IL-12 mRNA.

基于体外 mRNA 基因转导的细胞癌症免疫疗法进展

Advances in ex vivo mRNA-based gene transfer for cell-based cancer immunotherapy.

CX3CL1：细胞死亡免疫原性的关键开关

CX3CL1: a key switch of cell death immunogenicity.

mRNA 疫苗通过改变肿瘤微环境能在多大程度上影响免疫检查点抑制剂的反应性？来自黑色素瘤的证据

How Deeply Can mRNA Vaccines Affect the Responsiveness to Immune Checkpoint Inhibitors Through Changes in the Tumor Microenvironment? Evidence from Me

免疫肽组学鉴定出用于多发性骨髓瘤治疗的含α-半乳糖神经酰胺的 mRNA-脂质纳米颗粒疫苗的抗原

Immunopeptidomics identified antigens for mRNA-lipid nanoparticle vaccines with alpha-galactosylceramide in multiple myeloma therapy.

这些发现凸显了 Galsomes——一种旨在激活 CD8+ T 细胞和 iNKT 细胞的 mRNA 疫苗——在 MM 治疗中的潜力，并强调了联合治疗策略的重要性，即解决免疫无反应性以实现有效的 MM 免疫治疗。

BNT162b2 mRNA 疫苗接种影响滤泡性淋巴瘤和慢性淋巴细胞白血病患者的肠道微生物组组成

BNT162b2 mRNA vaccination affects the gut microbiome composition of patients with follicular lymphoma and chronic lymphocytic leukemia.

瘤内递送脂质纳米颗粒配制的编码 IL-21、IL-7 和 4-1BBL 的 mRNA 可诱导系统性抗肿瘤免疫

Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity.

α-半乳糖神经酰胺提高 mRNA LNP 疫苗对抗癌症和胞内细菌的效力

Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria.