差异 FGFR1 拷贝数状态在三阴性乳腺癌中展示独特的肿瘤免疫微环境
Differential FGFR1 copy number status displays unique tumour immune microenvironment in triple-negative breast cancer.
肿瘤细胞治疗研究
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Differential FGFR1 copy number status displays unique tumour immune microenvironment in triple-negative breast cancer.
Advances in Targeting Immune Checkpoint Inhibitors and New Vaccination Strategies for Triple-negative Breast Cancers: An Update.
TNBC-TME 是免疫治疗的靶点。当前的免疫治疗策略利用针对 PD-1、PD-L1 和 CTLA-4 的免疫检查点抑制剂(ICIs)靶向 TNBC TME。此外,多项研究致力于开发针对 TNBC TME 中免疫抑制细胞和分子的疫苗。本综述重点介绍了减轻 TNBC 的免疫治疗策略的进展,特别关注靶向免疫抑制分子。
Antibody-Drug Conjugates Synergize with Agonist Anti-CD137 Monoclonal Antibodies in Solid Tumors.
Perioperative Changes in Peripheral Natural Killer Cell Activity and Their Association With Clinicopathological Features in Breast Cancer: A Single-Ce
手术治疗似乎对乳腺癌患者外周血 NK 细胞活性产生有利影响。NK 活性变化与临床病理参数之间缺乏明确相关性,提示 NK 反应可能反映个体化的免疫能力,而非肿瘤特异性特征。需要整合 NK 细胞亚群和功能表型分析的大型前瞻性研究,以更好地界定 NK 细胞活性在乳腺癌中的预后和预测价值。
A Phase I/II Study of Ibrutinib Plus Trastuzumab in HER2-Positive Metastatic Breast Cancer.
The evolution of cellular therapies in sarcoma: Breakthroughs, challenges, and future directions.
Single-cell transcriptomic analysis reveals the immunosuppressive status of NK cell subpopulations in TNBC.
Dynamic Changes in Circulating and Tissue Biomarkers and Therapeutic Response to HER2/PD-1 Dual Blockade in HER2-Positive Gastric Cancer.
整合 ctDNA 和免疫生物标志物监测可能为双重 HER2/PD-1 阻断治疗提供预后信息。连续分子谱分析能够实现早期耐药检测,并识别可能指导治疗策略的进化模式,但仍需前瞻性验证。
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