人源 CAR-T22.19 治疗难治性儿童 B-ALL:指定患者队列的启示
Human CART22.19 therapy in refractory pediatric B-ALL: insights from a named-patient cohort.
CAR-T22.19 疗法在高危儿科人群中显示出良好的安全性特征和有前景的临床活性,其双靶向设计使 CD19 阴性白血病获得疾病控制。
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FOR TREATMENT
现在就能报名的(招募中)排在最前,共 2 项。同一状态内中国中心优先。信息来自 ClinicalTrials.gov 与 CDE 公开登记。能否入组、费用与可及性,以登记原文和主治医生判断为准。
FOR RESEARCH
Human CART22.19 therapy in refractory pediatric B-ALL: insights from a named-patient cohort.
CAR-T22.19 疗法在高危儿科人群中显示出良好的安全性特征和有前景的临床活性,其双靶向设计使 CD19 阴性白血病获得疾病控制。
Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia.
Live-cell Pick-Seq (LiP-Seq): Interrogating ultra-rare mantle cell lymphoma persistent cells after CART19 therapy.
A phase 1 clinical trial of NKTR-255 with CD19-22 CAR T-cell therapy for refractory B-cell acute lymphoblastic leukemia.
Bispecific CAR-T cells targeting CD19/20 in patients with relapsed or refractory B cell non-Hodgkin lymphoma: a phase I/II trial.
CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL.
CD19/CD22 bispecific CAR-T cells for MRD-positive adult B cell acute lymphoblastic leukemia: a phase I clinical study.
Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR.
CD34+CD19-CD22+ B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies.
Combining a CAR and a chimeric costimulatory receptor enhances T cell sensitivity to low antigen density and promotes persistence.
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