负载乙酰肝素酶的 CAR-T 细胞外囊泡重塑结直肠癌肿瘤微环境并增强 T 细胞抗肿瘤免疫
Heparanase-Loaded CAR T Extracellular Vesicles Remodel the Colorectal Tumour Microenvironment and Boost T Cell Antitumor Immunity.
嵌合抗原受体(CAR)T 细胞疗法在实体瘤中显示出前景,但其疗效受到致密细胞外基质(ECM)限制,后者阻碍 T 细胞进入。
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Heparanase-Loaded CAR T Extracellular Vesicles Remodel the Colorectal Tumour Microenvironment and Boost T Cell Antitumor Immunity.
嵌合抗原受体(CAR)T 细胞疗法在实体瘤中显示出前景,但其疗效受到致密细胞外基质(ECM)限制,后者阻碍 T 细胞进入。
Next-generation of mesothelin-targeted CAR-T cells secreting anti-PD-L1 scFv for potent immunotherapy against 3D patient-derived colorectal cancer org
最后,我们的14天离体CRC-PDOs/CAR-T平台为实体瘤中的肿瘤相关抗原验证、简化的PDO分离、自体CAR-T细胞毒性测试以及个性化免疫治疗优化提供了一种有前景的快速转化工具。
Persistence of activated anti-mesothelin hYP218 chimeric antigen receptor T cells in the tumour is associated with efficacy in gastric and colorectal
使用 TCGA 数据库中的人胃癌(n = 408)和结肠癌肿瘤(n = 275)进行 GEPIA 分析,以评估间皮素的 mRNA 表达,并与正常组织进行比较。
Design and development of dual targeting CAR protein for the development of CAR T-cell therapy against KRAS mutated pancreatic ductal adenocarcinoma u
突变 KRAS 促进多种癌症的增殖、转移和侵袭性,包括胰腺导管腺癌(PDAC)、非小细胞肺癌(NSCLC)和结直肠腺癌(CRC)。
Regional delivery of mesothelin-targeted chimeric antigen receptor T-cell effectively and safely targets colorectal cancer liver metastases in mice.
MSLN靶向CAR T细胞疗法的区域递送在原位CRLM NSG小鼠模型和PDX模型中具有令人鼓舞的结果,并将肿瘤微环境从冷肿瘤转化为热肿瘤。本研究可能为CRLM提供一种新的治疗途径。需要进一步的临床研究。
Disruption of adenosine 2A receptor improves the anti-tumor function of anti-mesothelin CAR T cells both in vitro and in vivo.
嵌合抗原受体(CAR)T 细胞已成功用于治疗血液系统恶性肿瘤,包括急性与慢性淋巴细胞白血病。
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