一种趋化因子"杠杆调控"仿生纳米制剂通过重塑免疫细胞生态位增强 CAR-T 细胞抗实体瘤作用
A chemokine "leverage regulation" biomimetic nanoformulation enhances CAR-T cells against solid tumors by reshaping immune cell niches.
驱动异常免疫细胞生态位的肿瘤趋化因子,在损害针对实体瘤的嵌合抗原受体(CAR)-T 细胞治疗中起关键作用。
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A chemokine "leverage regulation" biomimetic nanoformulation enhances CAR-T cells against solid tumors by reshaping immune cell niches.
驱动异常免疫细胞生态位的肿瘤趋化因子,在损害针对实体瘤的嵌合抗原受体(CAR)-T 细胞治疗中起关键作用。
Intrinsic immune properties of carrier MSC impact on the clinical outcome of children with solid tumors receiving oncolytic virotherapy.
具有减弱抗病毒先天免疫反应的载体MSCs——以低MAVS表达和减弱的促炎信号为特征——为溶瘤病毒的全身递送提供了治疗优势。
Construction and characterization of a novel secreted MsC-CAR-T cell in solid tumors.
CD47-SIRP 信号已被认为是重要的免疫检查点,阻断 CD47 已被证明是治疗实体瘤的一种潜在治疗策略。
Pregnancy-specific glycoproteins as molecular links between mesenchymal stromal cells and M2 macrophages in tissue repair: implications for cancer pro
经过对间充质基质细胞(MSCs)数十年的研究,它们尚未在临床方案中常规使用。
Engineered mesenchymal stem cell-derived extracellular vesicles: kill tumors and protect organs.
实体瘤导致了 90% 的癌症,且仍是死亡的主要原因。
Stromal cells in the tumor microenvironment: accomplices of tumor progression?
经过 10 余年的努力,免疫细胞在 TME 中的作用以及基于免疫细胞治疗肿瘤的策略发展迅速。
The role of MSCs and CAR-MSCs in cellular immunotherapy.
嵌合抗原受体(CAR)被T细胞(CAR-T细胞)、NK 细胞、树突状细胞和巨噬细胞广泛使用,它们在细胞免疫治疗中具有重要意义。
pH-sensitive tumor-tropism hybrid membrane-coated nanoparticles for reprogramming the tumor microenvironment and boosting the antitumor immunity.
所构建的HM-BPT系统有潜力成为一种有前景的纳米平台,用于联合癌症治疗。
EZH2, a prominent orchestrator of genetic and epigenetic regulation of solid tumor microenvironment and immunotherapy.
基于联合治疗以启用ICB可能为癌症患者提供生存获益。
The innate regenerome: Harnessing mesenchymal niches and engineered cytotoxic killers for solid tumor immunotherapy.
实体瘤通过MHC I类分子下调、基质屏障和T细胞耗竭逃逸适应性免疫,使传统免疫疗法在“冷”病灶中无效。
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