肿瘤细胞治疗研究
英文原题：Pregnancy-specific glycoproteins as molecular links between mesenchymal stromal cells and M2 macrophages in tissue repair: implications for cancer progression.
经过对间充质基质细胞（MSCs）数十年的研究，它们尚未在临床方案中常规使用。
经过对间充质基质细胞（MSCs）数十年的研究，它们尚未在临床方案中常规使用。尽管各种研究方向指出，MSCs的治疗作用主要归因于其分泌的分子，并且已经描述了若干此类分子，但显然仍需要进一步理解MSC生物学，才能使其成为治疗疾病的有效工具。这篇小型综述提出这样的观点：MSCs并非单独发挥作用，而是与巨噬细胞等其他细胞类型协同作用，以实现组织再生，或者在某些情况下导致不良后果。在此背景下，将讨论MSCs产生的妊娠特异性糖蛋白对巨噬细胞的可能影响，以及这对组织修复、癌症进展和实体瘤中CAR-T 细胞治疗的影响。
After some decades of research on mesenchymal stromal cells (MSCs), they are not yet routinely used in clinical protocols. Even though various lines of investigation have pointed out that MSCs are therapeutic mainly owing to their secreted molecules, and a number of such molecules have been described, it is apparent that further understanding of MSC biology is still required to make them effective tools to treat diseases. This mini-review brings the perspective that MSCs do not act alone, but rather in concert with other cell types such as macrophages, to bring about tissue regeneration or, in some instances, unwanted consequences. In this context, the possible effects of pregnancy-specific glycoproteins produced by MSCs on macrophages, and consequences of this for tissue repair, cancer progression, and chimeric antigen receptor T cell therapy in solid tumors will be discussed.
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