CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
免疫检查点抑制剂和 CAR-T 细胞疗法的心脏毒性
英文原题：Cardiotoxicity of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T-Cell Therapy.
查看英文原题
Cardiotoxicity of Immune Checkpoint Inhibitors and Chimeric Antigen Receptor T-Cell Therapy.
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中文摘要
在过去十年中，免疫治疗已经改变了肿瘤学，其适应症列表不断扩大。与任何治疗类别一样，这些药物伴随着不良事件，这些事件正日益被认识到，并对患者护理提出了新的挑战，扩展了心脏肿瘤学的范围。利用PubMed数据库，这篇叙述性综述总结了最常用的免疫疗法——免疫检查点抑制剂（ICIs）相关的心血管不良事件，重点关注ICI相关心肌炎的机制、流行病学、诊断、治疗和监测。我们还回顾了与ICI治疗相关的加速性动脉粥样硬化性疾病、心力衰竭、心肌病（包括应激性心肌病）、心律失常和心包疾病。最后，我们概述了CAR-T 细胞治疗相关的 cardiotoxicity，包括细胞因子释放综合征。
展开英文摘要原文
Over the last decade, immunotherapy has transformed oncology, with an ever-expanding list of indications. As with any therapeutic class, these agents are accompanied by adverse events that are increasingly recognized and pose new challenges for patient care expanding the scope of cardio-oncology.
Using the PubMed database, this narrative review summarizes the cardiovascular adverse events associated with the most commonly used immunotherapies, immune checkpoint inhibitors (ICIs), with a focus on the mechanisms, epidemiology, diagnosis, treatment, and monitoring of ICI-associated myocarditis.
We also review accelerated atherosclerotic disease, heart failure, cardiomyopathy (including stress-induced cardiomyopathy), arrhythmias, and pericardial disease related to ICI therapy.
Finally, we outline CAR T-cell therapy associated cardiotoxicity, including cytokine release syndrome.
论文信息
- 作者
- Naser A、Morgan AA、Zhang L
- 第一作者单位
- Department of Internal Medicine, Jacobi Medical Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.United States
- 通讯作者单位
- Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.United States
- 文献类型
- 综述
- 期刊
- Journal of cardiovascular development and disease2026 Aug 12
- 原文标识
- PubMed 42645856 · DOI 10.3390/jcdd13080385
在 PubMed 查看 → 出版商原文（DOI） 全文 PDF（PMC）· 可下载 治疗专题与资料阅读指南 资料来源与翻译说明 报告译文或资料问题 →