CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
迟发性人类疱疹病毒 6 型脑炎伴继发性噬血细胞性淋巴组织细胞增生症发生于 CAR-T 细胞治疗后
英文原题：Late-onset Human Herpesvirus 6 Encephalitis with Secondary Hemophagocytic Lymphohistiocytosis after CAR T-cell Therapy.
查看英文原题
Late-onset Human Herpesvirus 6 Encephalitis with Secondary Hemophagocytic Lymphohistiocytosis after CAR T-cell Therapy.
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中文摘要
人类疱疹病毒6型（HHV-6）脑炎在嵌合抗原受体（CAR）T细胞治疗后较为罕见，且通常发生在输注后早期。我们报告一例76岁弥漫性大B细胞淋巴瘤患者，在输注lisocabtagene maraleucel 14个月后发生迟发性HHV-6脑炎并继发噬血细胞性淋巴组织细胞增生症（HLH）。脑脊液（CSF）分析显示HHV-6B DNA水平升高，骨髓和CSF中均发现噬血现象。尽管接受了更昔洛韦和针对HLH的治疗，患者仍死于细菌感染。对于CAR-T 细胞治疗后出现持续发热、过度炎症、血细胞减少或神经系统症状的患者，即使治疗已过去很长时间，也应考虑HHV-6相关疾病。
展开英文摘要原文
Human herpesvirus 6 (HHV-6) encephalitis after chimeric antigen receptor (CAR) T-cell therapy is rare and it usually occurs early after infusion.
We report a case of a 76-year-old man with diffuse large B-cell lymphoma who developed late-onset HHV-6 encephalitis with secondary hemophagocytic lymphohistiocytosis (HLH) 14 months after the infusion of lisocabtagene maraleucel. A cerebrospinal fluid (CSF) analysis revealed elevated HHV-6B DNA levels, and hemophagocytosis was identified in both the bone marrow and CSF.
Despite ganciclovir and HLH-directed therapy, the patient died of a bacterial infection. HHV-6-associated disease should be considered even long after CAR T-cell therapy in patients with persistent fever, hyperinflammation, cytopenia, or neurological symptoms.
论文信息
- 作者
- Masuda K、Sota M、Kitamura A、Yoshida T、Tanigawa T、Takikawa K、Tozuka K、Sakamoto M
- 单位
- Division of Hematology, Department of Medicine, Keio University School of Medicine, Japan.Japan
- 期刊
- Internal medicine (Tokyo, Japan)2026 Aug 19
- 原文标识
- PubMed 42618274 · DOI 10.2169/internalmedicine.7887-26