RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题:Effects of a forest therapy camp on cancer survivors' stress, mood and natural killer cells in Korea.
Effects of a forest therapy camp on cancer survivors' stress, mood and natural killer cells in Korea.
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森林疗法可以很容易地应用于癌症幸存者。森林疗法营的积极心理效应通过森林疗法营参与者压力和情绪状态的改善以及血清素水平的升高得到证实。然而,由于缺乏显著的组间差异,需要对皮质醇和 NK 细胞进行后续评估。
本研究调查了参加韩国森林疗养营的癌症幸存者心理和生理指标的变化。
共有37名癌症幸存者(实验组19名,对照组18名)参与了本研究。在为期2晚3天的时间里,实验组参与者参加了森林疗法营,其中包括体操、步行、五感体验和冥想等活动。两组在森林疗法营前后均完成了自评问卷,以测量其压力水平和情绪状态剖面。采集血样以测量皮质醇、血清素和自然杀伤(NK)细胞的水平。
森林疗法营结束后,与对照组相比,实验组的压力水平降低(p = .031),总体情绪紊乱显著改善(p = .047)。血清素水平也显著升高(p < .001)。然而,与预测相反,实验组相对于对照组的皮质醇显著升高(p = .016)。此外,两组之间NK细胞没有显著差异。
This study investigated changes in psychological and physiological indices in cancer survivors who participated in a forest therapy camp in Korea.
A total of 37 cancer survivors (19 and 18 in the experimental and control groups, respectively) participated in this study. Over a 2-night and 3-day period, the participants in the experimental group took part in a forest therapy camp that included activities such as gymnastics, walking, five-senses experiences, and meditation. Both groups completed self-report questionnaires that measured their stress levels and profile of mood states, both before and after the forest therapy camp. Blood samples were collected to measure the levels of cortisol, serotonin, and natural killer (NK) cells.
After the forest therapy camp, the experimental group exhibited reduced stress levels ( p = .031) and a significant improvement in total mood disturbance ( p = .047) when compared with the control group. The level of serotonin also significantly increased ( p < .001). However, in contrast to the prediction, a significant increase in cortisol was noted in the experimental group relative to the control group ( p = .016). Moreover, no significant difference in NK cells was noted between the two groups.
Forest therapy can be easily applied to cancer survivors. The positive psychological effects of the forest therapy camp were confirmed by improvements in stress and mood states and the increased level of serotonin in forest therapy camp participants. However, there is a need for a follow-up evaluation of cortisol and NK cells due to the absence of significant between-group differences.
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