CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
英文原题：Infection Prevention and Management in Patients Living With Multiple Myeloma.
Infection Prevention and Management in Patients Living With Multiple Myeloma.
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多发性骨髓瘤（MM）的治疗格局因四联疗法和T细胞重定向免疫疗法的出现而发生了革命性变化。尽管这些进展带来了前所未有的缓解率和缓解持续时间，但同时也造成了严重的免疫抑制状态。感染是MM患者死亡的主要原因，也是导致其发病的重要原因。
本文探讨了MM患者感染的复杂情况，重点强调了护士在早期发现和管理中的职责。通过有针对性的预防和治疗策略，护士能够延长患者的生存期并改善其日常生活体验。
本文是一篇叙述性综述，关注MM患者感染的危险因素以及当前感染的预防和管理实践，并重点介绍面向护士的最新指南。
MM 感染的危险因素包括 MM 相关免疫系统功能障碍、疾病相关因素如肾功能衰竭、合并症以及治疗相关免疫抑制或血细胞减少。通过教育培养能力、通过结构化的医疗过渡支持自主性，以及通过护患关系维持关联性，肿瘤科护士可以减轻与现代 MM 治疗相关的感染风险。
The landscape of multiple myeloma (MM) treatment has been revolutionized by the emergence of quadruplet therapies and T-cell-redirecting immunotherapies. Although these advancements offer unprecedented responses and lengths of remission, they simultaneously create a profound state of immune compromise. Infection is a leading cause of death and a significant cause of morbidity in patients living with MM.
This article explores the complex landscape of infection in patients with MM, highlighting nurse responsibilities in early detection and management. Through targeted prevention and treatment strategies, nurses improve the longevity and the daily lived experiences of their patients.
This article is a narrative review of risk factors for infection and current practices for the prevention and management of infections in patients with MM, highlighting updated guidelines for nurses.
Risk factors for infection in MM include MM-related immune system dysfunction, disease-related factors such as renal failure, comorbid conditions, and treatment-related immunosuppression or cytopenias. By fostering competence through education, supporting autonomy through structured transitions of care, and maintaining relatedness through the patient-nurse relationship, oncology nurses can mitigate the infection risks associated with modern MM therapy.
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