RNF43 p.G659fs 通过 PI3K/AKT/mTOR 信号通路和 HLA-E 上调导致 MSI-high 结直肠癌中 NK 细胞功能障碍
RNF43 p.G659fs leads to natural killer cell dysfunction in MSI-high colorectal cancer through PI3K/AKT/mTOR signaling and HLA-E up-regulation.
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
免疫细胞 lncRNA 重编程肿瘤微环境
英文原题：Immune cell lncRNAs reprogram the tumor microenvironment.
查看英文原题
Immune cell lncRNAs reprogram the tumor microenvironment.
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中文摘要
长链非编码 RNA（lncRNA）调控肿瘤微环境（TME），但其在 TME 免疫细胞群中的细胞内在作用仍被低估。在本综述中，我们将焦点从癌细胞转向免疫区室，系统回顾免疫细胞内在 lncRNA 如何调控 CD8 + T 细胞耗竭、CD4 + T 细胞极化、NK 细胞细胞毒性、树突状细胞抗原呈递以及巨噬细胞炎症编程。我们重点介绍作为分子开关发挥作用的 lncRNA——使免疫细胞在抗肿瘤效应状态与免疫抑制状态之间倾斜——并探讨外泌体 lncRNA 如何将这些调控回路延伸至 TME 内跨细胞边界。最后，我们评估基于 lncRNA 的生物标志物和旨在靶向免疫格局的治疗机会，并概述将免疫内在 lncRNA 生物学整合到精准免疫肿瘤学中的框架。
展开英文摘要原文
Long noncoding RNAs (lncRNAs) regulate the tumor microenvironment (TME), yet their cell-intrinsic roles within immune populations of the TME remain underappreciated. In this review, we shift focus from the cancer cell to the immune compartment, systematically reviewing how immune cell-intrinsic lncRNAs govern CD8 + T cell exhaustion, CD4 + T cell polarization, NK cell cytotoxicity, dendritic cell antigen presentation, and macrophage inflammatory programming.
We highlight lncRNAs that function as molecular switches-tipping immune cells between antitumor effector and immunosuppressive states-and examine how exosomal lncRNAs extend these regulatory circuits across cellular boundaries within the TME.
Finally, we evaluate opportunities for lncRNA-based biomarkers and therapies designed to target the immune landscape, outlining a framework for integrating immune-intrinsic lncRNA biology into precision immuno-oncology.
论文信息
- 作者
- Bhadiadra C、Lin C、Yang L
- 第一作者单位
- Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Science, Houston, TX 77030, USA.United States
- 通讯作者单位
- Department of Molecular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Science, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: lyang7@mdanderson.org.United States
- 文献类型
- 综述
- 期刊
- Trends in cell biology2026 Jul 17
- 原文标识
- PubMed 42469035 · DOI 10.1016/j.tcb.2026.06.011