CAR-T（CAR-T）细胞疗法在非肿瘤性疾病中的应用
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.
CAR-T（CAR-T）细胞在血液系统恶性肿瘤中的应用推动了这种免疫治疗形式的显著进展。
CELL INTELLIGENCE · 肿瘤细胞治疗研究
肿瘤细胞治疗研究
类固醇抵抗性双侧面神经麻痹、眼肌麻痹与多节段胸神经根病作为 cilta-cel CAR-T 治疗后的免疫效应细胞相关迟发性神经毒性：一例病例报告及相似病例回顾
英文原题：Steroid-resistant bilateral facial nerve palsies, ophthalmoparesis, and multilevel thoracic radiculopathy as immune effector cell-associated late-onset neurotoxicity after cilta-cel CAR-T therapy: a case report and review of similar cases.
查看英文原题
Steroid-resistant bilateral facial nerve palsies, ophthalmoparesis, and multilevel thoracic radiculopathy as immune effector cell-associated late-onset neurotoxicity after cilta-cel CAR-T therapy: a case report and review of similar cases.
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中文摘要
近年来，CAR-T 细胞 疗法的使用变得更加广泛，最常用于治疗血液恶性肿瘤。这种疗法可能与神经毒性副作用有关。我们介绍了一名难治性多发性骨髓瘤患者，在接受 CAR-T 治疗后出现复视、双侧向上凝视受限、外展神经麻痹、双侧面神经麻痹和胸部感觉神经根病，这些症状被怀疑为迟发性免疫效应细胞相关神经麻痹 (IEC-NP)。尽管口服和静脉注射类固醇，他的症状仍在恶化。随后鞘内注射甲氨蝶呤和全身环磷酰胺导致症状急性改善，复视最终消失，眼外运动和面神经麻痹逐渐恢复。
展开英文摘要原文
The use of chimeric antigen receptor T-cell (CAR-T) therapy has become more widespread in recent years, most commonly for hematologic malignancies. This therapy can be potentially associated with neurotoxic side effects.
We present a patient with refractory multiple myeloma who developed diplopia, bilateral upward gaze limitation, abducens palsy, bilateral facial nerve palsy, and thoracic sensory radiculopathy following a course of CAR-T therapy, which were suspected to represent delayed immune effector cell-associated nerve palsies (IEC-NPs).
His symptoms progressed despite oral and intravenous steroids. Subsequent intrathecal methotrexate and systemic cyclophosphamide resulted in acute symptomatic improvement and eventual resolution of diplopia and gradual recovery of extraocular movements and facial nerve palsies.
论文信息
- 作者
- Johnson JR、Gupta T、Tavcar M、Glynn A、Hedera P
- 单位
- Department of Neurology, School of Medicine, University of Louisville, Louisville, KY, United States.United States
- 文献类型
- 病例报告
- 期刊
- Frontiers in neurology2026
- 原文标识
- PubMed 42444648 · DOI 10.3389/fneur.2026.1835346
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